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ProteomicsDual protein kinase/ nucleoside kinase modulat ors for rationally designed polypharmacology
Masitinib, a highly selective protein kinase inhibitor, can sensitise gemcitabine-refractory cancer cell lines when used in combination with gemcitabine. A reverse proteomic approach has identified the target responsible for this sensitisation: the deoxycytidine kinase (dCK). Masitinib, as well as o...
ORGANISM(S): Homo sapiens (Human) 
2017-11-13 | PXD007765 | Pride
Human Ltq-velos-orbitrap Labelfree 
ProteomicsHeme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer
In this project, we sought to identify the proteins interacting with the Elongin-C/Elongin-B complex. To this end, we performed affinity purification of Elongin-C and Elongin-B tagged with FLAG-STREP and MYC, respectively. A cell line with FLAG-STREP empty vector was used as negative control. 3 biol...
ORGANISM(S): Homo sapiens (Human) 
2026-06-11 | PXD062976 | Pride
Lc-msms  dia  elongin-c  elongin-b  cul2  cullin-ring ubiquitin ligase  crl2 
ProteomicsTitle Heme acts as a molecular degrader linking CRL2-FEM1B to substrate proteolysis and ferroptosis regulation in lung cancer
In this project, we attempted to explore the differential proteins profile of lung cancer cells in which the BACH1-CRL2 pathway was manipulated. To this end, we performed DIA-based quantitative proteomics in mouse lung adenocarcinoma KP cells. Control cells and BACH1 null cells were used. Additiona...
ORGANISM(S): Mus musculus (Mouse) 
2026-06-11 | PXD062953 | Pride
Kp  bach1  crl2  nsclc  lc-msms  dia 
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