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Genomics
MGCEP 1.0 RNA-seq under exogenous BGCs
PRJNA881032 | ENA
Genomics
Bioprospection of BGCs -draft genome of Aetherobacter fasciculatus
PRJEB72099 | ENA
ProteomicsAdrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism
Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their c...
ORGANISM(S): Streptomyces sp. MBT84 
2022-01-10 | PXD030484 | Pride
Streptomyces Bgcs Antibacteria Mbt84 Catechol 
ProteomicsAdrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism
Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their c...
ORGANISM(S): Streptomyces sp. MBT84 
2022-02-04 | PXD030319 | Pride
Streptomyces Bgcs Antibacteria Mbt84 Catechol 
MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
MetabolomicsHorizontal Transfer of Bacteriocin Biosynthesis Genes Requires Metabolic Adaptation To Improve Compound Production and Cellular Fitness

Biosynthetic gene clusters (BGCs) encoding the production of bacteriocins are widespread among bacterial isolates and are important genetic determinants of competitive fitness within a given habitat. Staphylococci produce a tremendous diversity of compounds, and the corresponding BGCs are frequen...

2022-11-09 | MTBLS5196 | MetaboLights
TranscriptomicsElucidation of genes enhancing natural product biosynthesis through co-evolution analysis
Streptomyces has the largest repertoire of natural product biosynthetic gene clusters (BGCs), yet developing a universal engineering strategy for each Streptomyces species is challenging. Given that some Streptomyces species have larger BGC repertoires than others, we hypothesized that a set of gene...
ORGANISM(S): Streptomyces griseus Streptomyces rapamycinicus 
2024-03-01 | GSE256209 | GEO
ProteomicsA family of lanthipeptides with anti-phage function
Bacteria produce natural products to adapt to their environments, with phage interactions as major ecological and evolutionary drivers. While some natural products protect bacteria from phages, the prevalence and diversity of chemical anti-phage defenses remain largely unexplored. Here, we identify ...
ORGANISM(S): Streptomyces albidoflavus 
2026-07-21 | PXD078908 | Pride
Biosynthetic gene clusters Lanthipeptide Actinobacteria Anti-phage defense Natural products 
TranscriptomicsThe potential functions of FOXL2 in different phases of chicken granulosa cells by RNA-seq
RNA-seq were performed to study the altered transcriptions by overexpression of FOXL2 in pre-hierarchical (SGCs) and pre-ovulatory granulosa cells (BGCs)
ORGANISM(S): Gallus gallus 
2017-01-12 | GSE76677 | GEO
ProteomicsGenome Mining of Monoterpenes from Ascidian-Derived fungus Diaporthe sp. SYSU-MS4722
Marine-derived fungi represent anunderexplored sourceofmonoterpenes, withonlysporadicreportsover thepast twodecades,makingtheir discovery particularlychallenging.Whole-genomesequencing of Diaporthesp. SYSU MS4722,anascidian-derivedfungusisolatedfromStyelaplicata, identified130 biosyntheticgenecluste...
ORGANISM(S): Diaporthe sp. T1 
2025-07-04 | PXD065442 | Pride
Genome mining q10 Phomoxanthone a Monoterpenes Antiinflammatoryactivity Polypropionate derivatives 
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