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TranscriptomicsParalogous MarR/DUF24-family repressors YodB and CatR control expression of the catechol dioxygenase CatE in Bacillus subtilis
The redox-sensing MarR/DUF24-type repressor YodB controls expression of the azoreductase AzoR1 and the nitroreductase YodC that are involved in detoxification of quinones and diamide in Bacillus subtilis. In the present paper, we identified YodB and its paralog YvaP (CatR) as repressors of the yfiDE...
ORGANISM(S): Bacillus subtilis 
2010-06-29 | E-GEOD-22603 | biostudies-arrayexpress
ProteomicsAdrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism
Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their c...
ORGANISM(S): Streptomyces sp. MBT84 
2022-02-04 | PXD030319 | Pride
Streptomyces Bgcs Antibacteria Mbt84 Catechol 
ProteomicsAdrenaline-mediated activation of antibiotic production in Streptomyces highlights catechol as elicitor of specialized metabolism
Actinobacteria are a rich source of bioactive molecules, and genome sequencing has shown that the vast majority of their biosynthetic potential has yet to be explored. However, many of their biosynthetic gene clusters (BGCs) are poorly expressed in the laboratory, which prevents discovery of their c...
ORGANISM(S): Streptomyces sp. MBT84 
2022-01-10 | PXD030484 | Pride
Streptomyces Bgcs Antibacteria Mbt84 Catechol 
TranscriptomicsFunctional profiling in yeast with the benzene metabolites hydroquinone, catechol and 1,2,4-benzenetriol
Benzene is a ubiquitous environmental contaminant and is widely used in industry. Exposure to benzene causes a number of serious health problems, including blood disorders and leukemia. Benzene undergoes complex metabolism in humans, making mechanistic determination of benzene toxicity difficult. We...
ORGANISM(S): Saccharomyces cerevisiae 
2013-03-13 | E-GEOD-45116 | biostudies-arrayexpress
ProteomicsIn-situ Click Reaction Coupled with Quantitative Proteomics for Identification of Protein Targets of Catechol Estrogens
Catechol estrogens (CEs) are metabolic electrophiles that actively undergo covalent interaction with cellular proteins, influencing molecular function. There is no feasible method to identify their binders in a living system. Herein, we developed a click chemistry-based approach using ethinylestradi...
ORGANISM(S): Rattus norvegicus (Rat) 
2022-02-28 | PXD009657 | Pride
Post translational modification Metabolites Proteomics Electrophiles Dimethyl labeling Lc/ms Catechol estrogens Oxidative stress Click chemistry Redox modification 
ProteomicsCatechol-modified protein extracts from human heart mitochondria after APBA chromatography
Catecholamine metabolism via monoamine oxidase (MAO) contributes to cardiac injury in models of ischemia and diabetes, but the pathogenic mechanisms involved are unclear. MAO deaminates norepinephrine (NE) and dopamine (DA) to produce H2O2 and highly reactive ‘catecholaldehydes,’ which may be toxic ...
ORGANISM(S): Homo sapiens (Human) 
2020-10-21 | PXD021759 | Pride
Mitochondrial proteomics Atrial mitocardium Mao Type 2 diabetes Catecholamine metabolism Atrial tissue Human Cardiomyopathy 
ProteomicsCatechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer cells. To delineate COMT role in metastasis of estrogen receptor dependent...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD033833 | Pride
Pulldown Breast cancer Comt Proteomics Dia 
ProteomicsIdentification of Cytosolic Protein Targets of Catechol Estrogens in Breast Cancer Cells Using a Click Chemistry-based Workflow
Catechol estrogens (CEs) are known to be toxic metabolites and the initiators in the oncogenesis of breast cancers via forming covalent adducts with DNAs. CEs shall also react with proteins but their cellular protein targets remain un-explored. Here we reported the identification of protein targets ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-28 | PXD017731 | Pride
Affinity purification Catechol estrogens Breast cancer cells Mass spectrometry Proteomic 
GenomicsGene expression in glucose-grown P. putida KT2440 before and after 5 mM catechol addition
Gene expression in glucose-grown P. putida KT2440 before and after 5 mM catechol addition
PRJNA805518 | ENA
Genomics
Microbial diversity in catechol sludge
PRJNA684631 | ENA
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