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MetabolomicsOverexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory

UV-B radiation regulates numerous morphogenic, biochemical and physiological responses in plants, and can stimulate some responses typically associated with other abiotic and biotic stimuli, including invertebrate herbivory. Removal of UV-B from the growing environment of various plant species ha...

2023-08-14 | MTBLS8236 | MetaboLights
GenomicsEnhancing glioblastoma radiotherapy by COMT inhibition
Enhancing glioblastoma radiotherapy by COMT inhibition
PRJNA993639 | ENA
GenomicsCynomolgus macaque Catechol-O-methyltransferase (COMT) Val158Met encoded polymorphism
Cynomolgus macaque COMT Val158Met encoded polymorphism
PRJEB65031 | ENA
TranscriptomicsEnhancing glioblastoma radiotherapy by COMT inhibition
Next-generation sequencing (NGS)-derived transcriptomic profiling was carried out to compare the transcriptomic changes mediated by COMT knockout in U87 cells. We found significant enrichment of gene signatures involving IFNa/b signaling in COMT-KO U87 cells compared to control cells. Our analysis a...
ORGANISM(S): Homo sapiens 
2023-10-12 | GSE237053 | GEO
GenomicsSingle-cell RNAseq of control and COMT-KO glioma tumors in mice.
Single-cell RNAseq of control and COMT-KO glioma tumors in mice.
PRJNA998358 | ENA
TranscriptomicsSimultaneous Downregulation of MTHFR and COMT in Switchgrass Affects Plant Performance and Induces Lesion-mimic Cell Death
Switchgrass (Panicum virgatum) has been developed into a model lignocellulosic bioenergy crop. Downregulation of caffeic acid O-methyltransferase (COMT), a key enzyme in lignin biosynthesis, led to altered lignification and increased biofuel yield in switchgrass. Methylenetetrahydrofolate reductase ...
ORGANISM(S): Panicum virgatum 
2018-05-01 | GSE98676 | GEO
TranscriptomicsSingle-cell RNAseq of control and COMT-KO glioma tumors in mice.
Next-generation sequencing (NGS)-derived transcriptomic profiling was carried out to compare the transcriptomic changes mediated by COMT knockout CT2A glioblastoma tumors using an orthotopic mouse model.
ORGANISM(S): Mus musculus 
2023-10-12 | GSE238199 | GEO
TranscriptomicsA systems biology view of responses to lignin biosynthesis perturbations in Arabidopsis
Inflorescence stems of 20 Arabidopsis thaliana mutants, each mutated in a single gene of the lignin biosynthetic pathway (PAL1 , PAL2, C4H, 4CL1, 4CL2, CCoAOMT1, CCR1, F5H1, COMT and CAD6, two mutant alleles each) were analyzed by microarrays.
ORGANISM(S): Arabidopsis thaliana 
2012-09-20 | E-MTAB-1284 | biostudies-arrayexpress
ProteomicsCatechol-O-methyl transferase suppresses cell invasion and interplays with MET signaling in estrogen dependent breast cancer
Catechol-O-methyl transferase (COMT) is involved in detoxification of catechol estrogens, playing cancer-protective role in cells producing or utilizing estrogen. Moreover, COMT suppressed migration potential of breast cancer cells. To delineate COMT role in metastasis of estrogen receptor dependent...
ORGANISM(S): Homo sapiens (Human) 
2023-01-31 | PXD033833 | Pride
Pulldown Breast cancer Comt Proteomics Dia 
UnknownAssociation of COMT and COMT-DRD2 interaction with creative potential.
Not available
S-EPMC3995040 | biostudies-literature
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