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ProteomicsA Lysosome membrane regeneration pathway depends on TBC1D15 and autophagic lysosomal reformation proteins
Acute lysosomal membrane damage reduces the cellular population of functional lysosomes. However, these damaged lysosomes have a remarkable recovery potential independent of lysosomal biogenesis and remain unaffected in TFEB/TFE3-depleted cells. We combined proximity labelling based proteomics, bioc...
ORGANISM(S): Homo sapiens (Human) 
2023-03-07 | PXD040191 | Pride
Autophagy Lysosomal regeneration Lysosomes Autophagic lysosomal reformation Tbc family of proteins 
ProteomicsFamotidine targets Toll-like receptor 3 signaling in SARS-CoV2 infection
Caco2 cells were pretreated with 100µM histamine and 50µM Famotidine for 12h followed by infection with SARS-CoV2 for 24h. After that proteome was analysed.
ORGANISM(S): Homo sapiens (Human) 
2022-02-17 | PXD025703 | Pride
Famotidine Sars-cov2 Toll-like receptor Histamine Anti-viral signaling 
TranscriptomicsTranscription profiling of mouse lung from E18, P1, P4, P7, P10, P14, P21, and adult) or pooled (E12, E14, E16) - developmental series
Mammalian lung development is a complex morphogenetic process, which initiates near mid-gestation and continues through early postnatal life. The lung arises as two lateral buds that emerge from the ventral foregut endoderm at ~ 9 days after fertilization (in mouse) and undergo numerous rounds of di...
ORGANISM(S): Mus musculus 
2008-06-11 | E-GEOD-10889 | biostudies-arrayexpress
TranscriptomicsDiverse routes to oral cancer differing in genome instability and risk for cervical node metastasis
Clinically evident oral lesions, oral epithelial dysplasia, precede development of oral squamous cell carcinomas (SCC) and are considered to transform to cancer by acquisition of genetic or epigenetic alterations. Here, we show that, +3q24-qter, -8pter-p23.1, +8q12-q24.2 and +20 are early events id...
ORGANISM(S): Homo sapiens 
2011-11-18 | E-GEOD-28407 | biostudies-arrayexpress
UnknownMolecular mapping of flowering traits revealed a major QTL, qDFFF3.3.1 associated with early maturity in cucumber (Cucumis sativus L.).
Not available
S-EPMC12817591 | biostudies-literature
UnknownT-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults.
Not available
S-EPMC9810235 | biostudies-literature
UnknownMolecular epidemiology of SARS-CoV-2 in healthcare workers and identification of viral genomic correlates of transmissibility and vaccine break through infection: A retrospective observational study from a cancer hospital in eastern India.
Not available
S-EPMC9558092 | biostudies-literature
ProteomicsCoronavirus PLPro interactome AP-MS data
Main proteases and papain-like proteases (PLpro) are essential coronaviral enzymes required for polypeptide processing during viral maturation. PLpro additionally cleave host cellular proteins to evade anti-viral immune responses. Here, we provide biochemical, structural and functional characterizat...
ORGANISM(S): Homo sapiens (Human) 
2020-08-05 | PXD018983 | Pride
Isgylation Ap-ms Sars-cov-2 Plpro 
UnknownPlacental genomics mediates genetic associations with complex health traits and disease.
Not available
S-EPMC8817049 | biostudies-literature
UnknownT-cell cellular stress and reticulocyte signatures, but not loss of naive T lymphocytes, characterize severe COVID-19 in older adults.
Not available
S-EPMC9838276 | biostudies-literature
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