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Amniotic fluid-derived products are a promising resource for cell therapy and tissue engineering due to their anti-inflammatory, angiogenic, and antifibrotic properties. Human amniotic fluid (hAF) has been used in medical applications such as wound healing, skin disorders, and ophthalmic conditions....
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD053775 | Pride
Heart disease is the leading cause of death in the developed world, and its comorbidities such as hypertension, diabetes, and heart failure are accompanied by major transcriptomic changes in the heart. During cardiac dysfunction, which leads to heart failure, there are global epigenetic alterations ...
ORGANISM(S): Mus musculus (Mouse) 
2022-10-14 | PXD031617 | Pride
Diabetic cardiomyopathy, an increasingly global epidemic and a major cause of heart failure with preserved ejection fraction (HFpEF), is associated with hyperglycemia, insulin resistance, and intra-cardiomyocyte calcium mishandling. Here we identify that, in db/db mice with type 2 diabetes induced H...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-24 | PXD044236 | Pride
Human genome-wide association studies (GWAS) of metabolic-associated steatohepatitis (MASH), the most common liver disease worldwide, have examined either liver injury biomarkers or liver fat content, with lipid metabolism enzymes ranked highly in both analyses. Here, to define pathophysiological pa...
ORGANISM(S): Mus musculus (Mouse) 
2026-07-30 | PXD069152 | Pride
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