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TranscriptomicsTranscription profiling of human neuroblastoma cell line IMR-32 overexpressiong SQSTM1 and DPP3 to identify activators for the antioxidant response element
The antioxidant response element (ARE) is a cis-acting regulatory enhancer element found in the 5’ flanking region of many phase II detoxification enzymes. Upregulation of ARE-dependent target genes is known to have neuroprotective effects; yet, the mechanism of activation is largely unknown. By scr...
ORGANISM(S): Homo sapiens 
2007-11-01 | E-GEOD-6451 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human peripheral blood lymphocytes: comparison between melanoma patients and healthy controls
We focused on the major peripheral blood lymphocyte populations that may be involved in anti-tumor responses and negatively impacted by cancer, specifically CD8 T cells, CD4 T cells, B cells and CD56dim natural killer cells. The pure cell subsets were stringently sorted by flow cytometry from PBMC s...
ORGANISM(S): Homo sapiens 
2008-06-15 | E-GEOD-6887 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution CRISPR Screens Reveal Fitness Genes and Genotype-Specific Cancer Liabilities
The ability to perturb genes in human cells is crucial for elucidating gene function and holds great potential for finding therapeutic targets for diseases such as cancer. To extend the catalog of human core and context- dependent fitness genes, we have developed a high-complexity second-generation ...
ORGANISM(S): Homo sapiens 
2015-11-25 | E-GEOD-75189 | biostudies-arrayexpress
TranscriptomicsThe ets transcription factor ELF5 suppresses the estrogen sensitive phenotype and contributes to antiestrogen resistance in luminal breast cancer. [human]
The ets transcription factor ELF5 specifies the differentiation of mammary progenitor cells to establish the milk-secreting lineage. ER- and poor prognosis basal breast cancers arise from this progenitor cell and these cancers express high levels of Elf5. Knockdown of ELF5 expression in basal breast...
ORGANISM(S): Homo sapiens 
2012-12-27 | E-GEOD-30405 | biostudies-arrayexpress
TranscriptomicsGene expression of rat PSCs cultured on plastic, matrigel and collagen
Activated pancreatic stellate cells produce the fibrotic matrix in chronic pancreatitis and pancreatic cancer. In vitro protocols examining PSC biology have usually involved PSCs cultured on plastic, a non-physiological surface. However, PSCs cultured on physiological matrices e.g. MatrigelTM (norma...
ORGANISM(S): Rattus norvegicus 
2013-01-17 | E-GEOD-43496 | biostudies-arrayexpress
TranscriptomicsERK signaling regulates opposing functions of JUN family transcription factors in prostate cancer cell migration
Knockdowns of c-JUN and JUND had opposite effects on PC3 prostate cell migration. We predicted that c-JUN and JUND control the same set of cell migration genes, but in opposite directions. To test this hypothesis, mRNA with expression changes in c-JUN and JUND knockdown PC3 cell lines were compared ...
ORGANISM(S): Homo sapiens 
2014-10-23 | E-GEOD-53470 | biostudies-arrayexpress
TranscriptomicsETS1 is a genome-wide effector of RAS/ERK signaling in epithelial cells (RNA-Seq)
ETS1 and RAS/ERK regulate a common gene expression program in establishing enviroment suitable for prostate cancer cell migration. mRNA profiles of luciferase knockdown (WT), ETS1 knockdown, and U0126 treated DU145 cells were generated using deep sequencing, in triplicate, using Illumina HiSeq. Knoc...
ORGANISM(S): Homo sapiens 
2014-10-07 | E-GEOD-59020 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization of human breast cancer cell lines (45) on Affymetrix 100K SNP arrays
Breast cancer cell lines grown in full serum under standard conditions were profiled on Affymetrix GeneChip Mapping 100K Set Arrays Experiment Overall Design: Profiling of cell lines grown under standard conditions
ORGANISM(S): Homo sapiens 
2009-05-01 | E-GEOD-13696 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat smooth muscle cells modulated by rapamycin and paclitaxel
Background: Drug-eluting stents (DES) have rapidly become a standard therapy for treatment of obstructive coronary artery disease. Differences exist in therapeutic responses to different DES formulations, and mechanisms to predict drug responses in the preclinical setting have not been standardized....
ORGANISM(S): Rattus norvegicus 
2008-06-14 | E-GEOD-5337 | biostudies-arrayexpress
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