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ProteomicsThe Kinase CK1a coordinates Initiation and Termination of the cGAS-STING Pathway
The cGAS-STING pathway is an evolutionarily conserved antimicrobial defense mechanism that senses cytosolic DNA to trigger innate immune responses. cGAS and STING play dual roles in tumorigenesis, promoting antitumor immunity and cell death while fueling tumor growth and metastasis. However, the mec...
ORGANISM(S): Homo sapiens (Human) 
2026-09-10 | PXD063855 | Pride
Biotin Apex Lc-ms Cgas/ting Ap-ms Ck1-alpha 
ProteomicsThe Centriolar Satellite Component CEP131 timely regulates mitochondrial Apoptosis
Centriolar satellites are multiprotein aggregates that orbit the centrosome and govern centrosome homeostasis and primary cilia formation. In contrast to the scaffold PCM1, which nucleates centriolar satellites and has been linked to microtubule dynamics, autophagy, and intracellular trafficking, th...
ORGANISM(S): Homo sapiens (Human) 
2024-01-26 | PXD042470 | Pride
Mitochondria Centriolar satellites Cep131 Apoptosis 
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