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TranscriptomicsSynergism of calcium sensing receptor and vitamin D receptor mediated signaling in epidermal differentiation [double KO]
Calcium and 1,25-dihydroxyvitamin D3 (1,25D3), through the actions of their respective receptors, the Ca2+-sensing receptor (CaSR) and the vitamin D receptor (VDR), potentiate keratinocyte differentiation. VDR regulates epidermal keratinocyte proliferation and differentiation by modulating gene tran...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68725 | biostudies-arrayexpress
TranscriptomicsSynergism of calcium sensing receptor and vitamin D receptor mediated signaling in epidermal differentiation [VDR KO]
Calcium and 1,25-dihydroxyvitamin D3 (1,25D3), through the actions of their respective receptors, the Ca2+-sensing receptor (CaSR) and the vitamin D receptor (VDR), potentiate keratinocyte differentiation. VDR regulates epidermal keratinocyte proliferation and differentiation by modulating gene tran...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68723 | biostudies-arrayexpress
TranscriptomicsVitamin D receptor (VDR) regulates epidermal stem cells and cutanous wound healing [keratinocytes]
The vitamin D receptor (VDR) regulates cell proliferation and differentiation including epidermal keratinocytes by modulating transcription of its target genes. We are investigating the role of VDR in epidermal stem cells and their progenies in the regeneration process of epidermis and hair in the s...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68729 | biostudies-arrayexpress
TranscriptomicsVitamin D receptor (VDR) regulates epidermal stem cells and cutanous wound healing [VDR KO]
The vitamin D receptor (VDR) regulates cell proliferation and differentiation including epidermal keratinocytes by modulating transcription of its target genes. We are investigating the role of VDR in epidermal stem cells and their progenies in the regeneration process of epidermis and hair in the s...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68727 | biostudies-arrayexpress
TranscriptomicsVitamin D receptor (VDR) regulates epidermal stem cells and cutanous wound healing [BKO]
The vitamin D receptor (VDR) regulates cell proliferation and differentiation including epidermal keratinocytes by modulating transcription of its target genes. We are investigating the role of VDR in epidermal stem cells and their progenies in the regeneration process of epidermis and hair in the s...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68728 | biostudies-arrayexpress
TranscriptomicsSynergism of calcium sensing receptor and vitamin D receptor mediated signaling in epidermal differentiation [CaSR KO]
Calcium and 1,25-dihydroxyvitamin D3 (1,25D3), through the actions of their respective receptors, the Ca2+-sensing receptor (CaSR) and the vitamin D receptor (VDR), potentiate keratinocyte differentiation. VDR regulates epidermal keratinocyte proliferation and differentiation by modulating gene tran...
ORGANISM(S): Mus musculus 
2015-07-31 | E-GEOD-68724 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-50504 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair [mixed stage]
Cell fate is defined by specific transcriptional program. Here, we provide evidence that the transcriptional coactivator, Mediator 1 (MED1), is critical in determining the cell fate of ectodermal epithelia. MED1 ablation disrupted enamel formation and generated hair adjacent to the incisors. Deletio...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-50503 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair [maturation stage]
Cell fate is defined by specific transcriptional program. Here, we provide evidence that the transcriptional coactivator, Mediator 1 (MED1), is critical in determining the cell fate of ectodermal epithelia. MED1 ablation disrupted enamel formation and generated hair adjacent to the incisors. Deletio...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-50502 | biostudies-arrayexpress
TranscriptomicsAblation of coactivator Med1 switches the cell fate of dental epithelia to that generating hair [CL stage]
Cell fate is defined by specific transcriptional program. Here, we provide evidence that the transcriptional coactivator, Mediator 1 (MED1), is critical in determining the cell fate of ectodermal epithelia. MED1 ablation disrupted enamel formation and generated hair adjacent to the incisors. Deletio...
ORGANISM(S): Mus musculus 
2013-09-23 | E-GEOD-50501 | biostudies-arrayexpress
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