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TranscriptomicsOncostatin M effects in IMR90 cells
The JAK2 mutation V617F is detectable in a majority of patients with Ph-negative myeloproliferative neoplasms (MPN). Enforced expression of JAK2 V617F in mice induces myeloproliferation and bone marrow (BM) fibrosis suggesting a causal role for the JAK2 mutant in the pathogenesis of MPN. However, li...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-29655 | biostudies-arrayexpress
UnknownAPMAP interacts with lysyl oxidase-like proteins, and disruption of <i>Apmap</i> leads to beneficial visceral adipose tissue expansion.
Not available
S-EPMC5566180 | biostudies-literature
TranscriptomicsGene expression profiling of interferon-beta stimulated cells
Cytoplasmic DNA triggers the activation of the innate immune system. While downstream signaling components have been characterized, the DNA sensing components remain largely elusive. We performed a systematic proteomics screen for proteins that associate with DNA, traversed to a screen for IFN-β-ind...
ORGANISM(S): Mus musculus 
2009-01-14 | E-GEOD-14413 | biostudies-arrayexpress
TranscriptomicsCommon pathways involved in adipose tissue inflammation and atherosclerosis
Adipose tissue inflammation and atherosclerosis are the main mechanisms behind type 2 diabetes and cardiovascular disease respectively, the major risks associated with the metabolic syndrome. Studies considering more than single factors behind the complexity of the metabolic syndrome are valuable to...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-76812 | biostudies-arrayexpress
UnknownNanopore sequencing unveils the complexity of the cold-activated murine brown adipose tissue transcriptome.
Not available
S-EPMC10410515 | biostudies-literature
TranscriptomicsComparison of two hepatocellular cancer cell lines with distinct properties regarding epithelial-mesenchymal transition
The epithelial to mesenchymal transition (EMT) of malignant hepatocytes is a crucial event in hepatocellular carcinoma (HCC) progression and recurrence. We aimed to establish a human model of EMT to examine drug efficacy and specificity in HCC progression. Human HCC cell populations were characteriz...
ORGANISM(S): Homo sapiens 
2011-11-21 | E-GEOD-26391 | biostudies-arrayexpress
TranscriptomicsGene expression signatures of HO-1 in BeWo cells
Heme Oxygenase-1 (HO-1) is expressed in many cancers and influences the growth, survivall and metastasis of tumors, however, the molecular mechanisms remains largely unknown. To identify a common mechanism of action of HO-1 in cancer, we studied the global effect of HO-1 on the transcriptome of mul...
ORGANISM(S): Homo sapiens 
2011-02-15 | E-GEOD-20404 | biostudies-arrayexpress
TranscriptomicsAffymetrix SNP array data for a melanoma lesion and a cellline derived thereof
Here we report on a bulk culture termed MCM1, which was derived from a 61 year old male diagnosed with a nodular melanoma stage T2a, N0. At passage three of culturing, DNA was isolated and Affymetrix SNP6.0 array hybridizations were performed. Cultured MCM1 cells revealed overall identical copy numb...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-35991 | biostudies-arrayexpress
TranscriptomicsRegulation of gene expression in murine liver by IL-6
STEAP4 is a plasma membrane metallo-reductase involved in the transport of iron and copper. Recently, STEAP4 was implicated in promoting insulin sensitivity by acting in white adipose tissue (WAT) to control the production of inflammatory cytokines such as IL-6. Indeed, the loss of STEAP4 expression...
ORGANISM(S): Mus musculus 
2010-04-08 | E-GEOD-21060 | biostudies-arrayexpress
UnknownKRAS mutated lung adenocarcinoma responds to pan-ERBB and Aurora kinase inhibitors.
Not available
S-EPMC12796156 | biostudies-literature
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