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MetabolomicsSynergistic metabolism of salivary MUC5B in oral commensal bacteria during early biofilm formation

Bacterial metabolism in oral biofilms is comprised of complex networks of nutritional chains and biochemical regulations. These processes involve both intraspecies and interspecies networks as well as interactions with components from host saliva, gingival crevicular fluid, and dietary intake. In...

2023-10-30 | MTBLS8370 | MetaboLights
MetabolomicsPatA mediates biofilm formation and drugs resistance through regulating the synthesis of glycolipids and lipids in mycobacterium PatA mediates a novel mycolic acid synthesis pathway and regulates biofilm formation in mycobacterium
Glycolipids and lipids are prominent components of bacterial cell wall that play critical roles not only in maintaining the biofilm formation but also in resistance to environmental stress. PatA is an essential membrane associated acyltransferase involved in the biosynthesis of phosphatidyl-myo-inos...
2023-05-22 | MTBLS6758 | MetaboLights
MetabolomicsLC-MS/MS metabolomics unravels the resistant phenotype of carbapenemase-producing Enterobacteriaceae

Introduction: The degree of antimicrobial resistance demonstrated by carbapenemase-producing Enterobacteriaceae (CPE) represents a growing public health challenge. Conventional methods for detecting CPE involve culture-based techniques with lengthy incubation steps. There is a ne...

2025-08-04 | MTBLS10129 | MetaboLights
ProteomicsHistone-like family of nucleoid structuring protein of A. actinomycetemcomitans promotes biofilm formation and alters protein dynamics of other species within multi-species biofilm
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like...
ORGANISM(S): Candida albicans (Yeast) Aggregatibacter aphrophilus Streptococcus mutans Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum Veillonella dispar Actinomyces oris 
2018-06-05 | PXD008444 | Pride
Multi-species biofilm Hns A. actinomycetemcomitans Label-free quantification 
TranscriptomicsTranscription profiling of E. coli K-12 wild type with R1drd19 biofilm vs wild type without R1drd19 biofilm
E. coli K-12 wild type strains gene expression in biofilm cells with R1drd19 relative to that in biofilm cells of E. coli K-12 wild type strains without R1drd19. All the samples were cultured in LB or M9C glu on glass wool at different time. Experiment Overall Design: Strains: E. coli K-12 strains ...
ORGANISM(S): Escherichia coli 
2008-04-05 | E-GEOD-6923 | biostudies-arrayexpress
TranscriptomicsSarZ is a key regulator of biofilm formation and virulence in Staphylococcus epidermidis
Biofilm-associated infection by the leading nosocomial pathogen Staphylococcus epidermidis is a major problem for the public health system. Here we used an especially discriminatory, two-step screen to discover key biofilm factors. We identified the transcriptional regulator and SarA paralog SarZ as...
ORGANISM(S): Staphylococcus epidermidis 
2010-05-25 | E-GEOD-8523 | biostudies-arrayexpress
ProteomicsMajor Proteomic Changes Associated with Amyloid Induced Biofilm Formation in Pseudomonas aeruginosa PAO1
The newly identified functional amyloids in Pseudomonas (Fap) are associated with increased aggregation and biofilm formation in the opportunistic pathogen P. aeruginosa. However, whether this phenomenon can be simply ascribed to the mechanical properties of the amyloid fibrils remains...
ORGANISM(S): Pseudomonas Aeruginosa Pao1 (ncbitaxon:208964) 
MSV000082917 | MassIVE
TranscriptomicsPseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant
Microarray analysis for the biofilm cells of Pseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant in LB medium at 4 and 7 h at 37C Microarray analysis for the biofilm cells of Pseudomonas aeruginosa PA14 wild-type vs the tpbA (PA14_13660) mutant in LB medium at 4 and 7 h at 37C.
ORGANISM(S): Pseudomonas aeruginosa 
2009-05-23 | E-GEOD-13871 | biostudies-arrayexpress
TranscriptomicsStreptococcus pneumoniae in a biofilm are hyper-adhesive, avirulent, and when used as a killed whole-cell vaccine confers protection against lethal challenge
For Streptococcus pneumoniae, biofilms have been suggested to promote long-term colonization of the nasopharynx and contribute to the pathology of recurrent middle ear infections. To date numerous studies have investigated the contribution of specific genetic determinants for the development of pneu...
ORGANISM(S): Streptococcus pneumoniae 
2013-04-01 | E-GEOD-26976 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E.coli ydgG mutant vs. isogenic wild type in a mature biofilm
The E. coli Genechip antisense genome array was used to study the differential gene expression profile of E. coli K12 ydgG mutant compared to its isogenic wild type in a mature biofilm. Experiment Overall Design: Overnight cultures were diluted 100X into 1 L shake flasks containing 250 mL of LB + 0....
ORGANISM(S): Escherichia coli 
2008-06-12 | E-GEOD-3514 | biostudies-arrayexpress
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