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TranscriptomicsBioinformatics-based selection of a model cell type for in vitro biomaterial testing
Biomaterial properties can be tailored for specific applications via systematic and high-throughput screening of biomaterial–cell interactions. However, progress in material development is often hampered by the lack of adequate in vitro testing methods, frequently due to incomplete understanding of ...
ORGANISM(S): Homo sapiens 
2018-08-12 | E-MTAB-7057 | biostudies-arrayexpress
TranscriptomicsHigh content imaging in the screening of biomaterial-induced MSC behavior
Upon contact with a biomaterial, cells and surrounding tissues respond in a manner dictated by the physicochemical and mechanical properties of the material. Traditionally, cellular responses are monitored using invasive analytical methods that report the expression of genes or proteins. These analy...
ORGANISM(S): Homo sapiens 
2018-11-10 | E-MTAB-7352 | biostudies-arrayexpress
TranscriptomicsGene expression microrarray of MSC grown on bone inducing scaffolds
Mesenchymal Stem Cells have been seeded on calcium based biomaterials. Gene expression is evaluated at day 0 (unseeded cells), day 5, and day 10, in order to study differential expressions at different time points and infer if biomaterial induced gene expression variation able to differentiate stem ...
ORGANISM(S): Homo sapiens 
2016-01-29 | E-MTAB-3440 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of MG-63 cells grown on different biomaterials used in bone grafts
During the past decades, there have been major advances in the field of biomaterials, thereby generating a vast variety of materials for a broad range of tissue engineering and regeneration applications. Although gene expression profiling has been used occasionally in biomaterial research, its usefu...
ORGANISM(S): Homo sapiens 
2018-10-05 | E-MTAB-7219 | biostudies-arrayexpress
ProteomicsComparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes Comparative proteomic analysis of skin wound healing responses to biomaterial treatments identifies key pathways which govern differential regenerative outcomes
The wound healing cascade is characterized by the steady progression of distinct stages. Though biomaterials are used clinically to enhance wound closure rate and quality of healed tissue, their mechanisms of action are less understood. Here we use proteomic analysis to characterize changes in the w...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-15 | PXD067152 | Pride
Proteomics Regeneration Wound healing Gene ontology Chirality Map scaffold 
TranscriptomicsSparse feature selection methods identify unexpected global cellular response to strontium-containing materials
Despite the increasing sophistication of biomaterials design and functional characterization studies, little is known regarding cells' global response to biomaterials. Here, we combined nontargeted holistic biological and physical science techniques to evaluate how simple strontium ion incorporation...
ORGANISM(S): Homo sapiens 
2018-11-25 | E-MTAB-7384 | biostudies-arrayexpress
ProteomicsThe impact of biomaterial cell contact on the immunopeptidome
Biomaterials play an increasing role in clinical applications and regenerative medicine. Modern biomaterials should imitate the function of damaged tissue without triggering an immune response, initiate self-regeneration of the body and gradually degrade after implantation. The immune system is now ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD019258 | Pride
Monocytes Foreign body response Biocompatibility Mass spectrometry Immunopeptidomics Host response Biocompatibility assay Biomaterials 
GenomicsEngineered biomaterial immunological niches to monitor anti-VLA4 therapy in chronic progressive EAE
Engineered biomaterial immunological niches to monitor anti-VLA4 therapy in chronic progressive EAE
PRJNA1498100 | ENA
TranscriptomicsEngineered biomaterial immunological niches to monitor anti-VLA4 therapy in chronic progressive EAE
We use a subcutaneous biomaterial implant as a surrogate for sampling immune cells phenotypes in murine chronic EAE. These implants are microporous polycaprolactone scaffolds that form immunological niches that get vascularized and capture both innate and adaptive immune cells. These niches can be e...
ORGANISM(S): Mus musculus 
2026-09-03 | GSE339284 | GEO
TranscriptomicsEngineered biomaterial immunological niches as a surrogate for diseased tissue in chronic progressive EAE
We use a subcutaneous biomaterial implant as a surrogate for sampling immune cells phenotypes in murine chronic EAE. These implants are microporous polycaprolactone scaffolds that form immunological niches that get vascularized and capture both innate and adaptive immune cells. These niches can be m...
ORGANISM(S): Mus musculus 
2025-01-24 | GSE287968 | GEO
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