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ProteomicsBioorthogonal Photocatalytic Proximity Labeling in Primary Living Samples
In situ profiling of subcellular proteomic networks in primary and living systems, such as primary cells from native tissues or clinic samples, is crucial for the understanding of life processes and diseases, yet challenging for the current proximity labeling methods (e.g., BioID, APEX) due to their...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2024-05-24 | PXD045791 | Pride
Proximity labeling Mitochondria Bioorthogonal chemistry Photocatalysis 
ProteomicsChemical Proteomic Profiling of Lysine Crotonylation by Bioorthogonal Probes in Mammalian Cells
we report an alkynyl-functionalized bioorthogonal chemical probe, Cr-alkyne, for the detection and identification of protein lysine crotonylation in mammalian cells.
ORGANISM(S): Homo Sapiens 
PXD053632 |
ProteomicsTHRONCAT: Efficient metabolic labelling of newly synthesized proteins using a bioorthogonal threonine analogue
Profiling the nascent cellular proteome and capturing early proteomic changes in response to external stimuli provides valuable insight into cellular physiology. Existing metabolic protein labelling approaches based on bioorthogonal methionine- or puromycin analogueues allow for the selective visual...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD032368 | Pride
Throncat Boncat Lc-ms/ms 
UnknownA bioorthogonal quadricyclane ligation.
Not available
S-EPMC3206493 | biostudies-literature
UnknownDesign strategies for bioorthogonal smart probes.
Not available
S-EPMC4259128 | biostudies-literature
UnknownCell-surface Labeling via Bioorthogonal Host-Guest Chemistry.
Not available
S-EPMC9527085 | biostudies-literature
ProteomicsA Bioorthogonal Chemical Reporter for the Detection and Identification of Protein Lactylation
L-Lactylation is a recently discovered post-translational modification occurring on histone lysine residues to regulate gene expression. However, the substrate scope of lactylation, especially that in non-histone proteins, remains unknown, largely due to the limitations of current methods for analyz...
ORGANISM(S): Homo sapiens (Human) 
2022-06-23 | PXD033454 | Pride
Chemical reporter Chemical proteomics Lactylation 
UnknownIn situ activation of therapeutics through bioorthogonal catalysis.
Not available
S-EPMC8440397 | biostudies-literature
UnknownInterfacial Bioorthogonal Cross-Linking.
Not available
S-EPMC4144716 | biostudies-literature
UnknownBioorthogonal Reactions in Activity-Based Protein Profiling.
Not available
S-EPMC7765892 | biostudies-literature
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