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ProteomicsTHRONCAT: Efficient metabolic labelling of newly synthesized proteins using a bioorthogonal threonine analogue
Profiling the nascent cellular proteome and capturing early proteomic changes in response to external stimuli provides valuable insight into cellular physiology. Existing metabolic protein labelling approaches based on bioorthogonal methionine- or puromycin analogueues allow for the selective visual...
ORGANISM(S): Homo sapiens (Human) 
2023-07-20 | PXD032368 | Pride
Throncat Boncat Lc-ms/ms 
UnknownTHRONCAT: metabolic labeling of newly synthesized proteins using a bioorthogonal threonine analog.
Not available
S-EPMC10250548 | biostudies-literature
ProteomicsLiver-metastases restrict IL18-driven γδ T cell activity and immunotherapy responsiveness in colorectal cancer
To see how the secretome changes upon challenging organoids with immune pressure, we wanted to perform secretomics on CRC MSI organoids +- stimulation with IFNy. Secretomics was performed using a previously published metabolic labeling method based on threonine-derived non-canonical amino acid taggi...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD071538 | Pride
ProteomicsProteome and secretome profiling of type 3 dendritic cells
Dendritic cells (DCs) are professional antigen presenting cells endowed with the capacity to initiate strong antitumor immune responses. This function is critical for effective DC-based immunotherapies, but is often hampered by tumor-derived immunosuppressive factors, as is observed for CD14+CD163+ ...
ORGANISM(S): Homo sapiens (Human) 
2025-08-07 | PXD058584 | Pride
Human Dendritic cells Throncat Secretome Lc-ms/ms 
ProteomicsCancer cell-intrinsic rewiring of the colorectal cancer secretome
Secreted factors are essential mediators of cellular communication that are exploited by tumors to control their environment and evade immune attack. However, how cancer cells rewire their secretome is largely unclear due to challenges in reliably profiling cancer cell-specific secreted factors. Her...
ORGANISM(S): Homo sapiens (Human) 
2026-08-28 | PXD078528 | Pride
Organoids Notum Proteomics Colorectal cancer Secretome Throncat 
UnknownProteome and Secretome Profiling of the Melanoma-Induced Transition Toward Immune Incompetent Dendritic Cells Reveals Enhanced IDO1, Cathepsin, and Legumain Activity.
Not available
S-EPMC12454896 | biostudies-literature
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