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MetabolomicsProduction of chain-extended cinnamoyl compounds by overexpressing two adjacent cluster-situated LuxR regulators in Streptomyces globisporus C-1027

Natural products from microorganisms are important sources for drug discovery. With the development of high-throughput sequencing technology and bioinformatics, a large amount of uncharacterized biosynthetic gene clusters (BGCs) in microorganisms have been found, which show the potential for nove...

2023-09-06 | MTBLS5152 | MetaboLights
MetabolomicsOmics-guided global rewiring of yeast metabolism enables high-level production of β-lactoglobulin
This project contains untargeted metabolomic data generated to investigate the metabolic responses of Komagataella phaffii during methanol-free recombinant beta-lactoglobulin production. The study included the bovine beta-lactoglobulin-producing strain B08 and the feline beta-lactoglobulin-producing...
2026-06-05 | MTBLS14680 | MetaboLights
UnknownFeasibility analysis of automated cleaning in biopharmaceutical production using cleaning-in-place concepts from food production.
Not available
S-EPMC12497818 | biostudies-literature
ProteomicsA Sensitive, Rapid, Robust and Reproducible Workflow for Host Cell Protein Profiling in Biopharmaceutical Process Development
There is a growing industry and regulatory need to detect host cell protein (HCP) impurities in the production of protein biopharmaceuticals, as certain HCPs can impact product stability, safety, and efficacy, even at low levels.1-6 In some cases, regulatory agencies require the identification as we...
ORGANISM(S): Mus musculus (Mouse) 
2020-06-02 | PXD018427 | Pride
Monoclonal antibody (mab) Drug product (dp) Evosepone Drug substance (ds) Host cell proteins (hcps) Lc-ms/ms 
UnknownScaling-down biopharmaceutical production processes via a single multi-compartment bioreactor (SMCB).
Not available
S-EPMC9815078 | biostudies-literature
UnknownMultiplexed Microfluidic Cartridge for At-Line Protein Monitoring in Mammalian Cell Culture Processes for Biopharmaceutical Production.
Not available
S-EPMC8034812 | biostudies-literature
UnknownThe utility of hydrogen/deuterium exchange mass spectrometry in biopharmaceutical comparability studies.
Not available
S-EPMC3164548 | biostudies-literature
UnknownBioreactor control systems in the biopharmaceutical industry: a critical perspective.
Not available
S-EPMC8340809 | biostudies-literature
UnknownProcess Engineering of Biopharmaceutical Production in Moss Bioreactors via Model-Based Description and Evaluation of Phytohormone Impact.
Not available
S-EPMC8891706 | biostudies-literature
UnknownA mammalian artificial chromosome engineering system (ACE System) applicable to biopharmaceutical protein production, transgenesis and gene-based cell therapy.
Not available
S-EPMC535698 | biostudies-literature
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