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ProteomicsCab45-dependent facilitation of insulin secretory granule biogenesis and its dysregulation in type 2 diabetes
Germanos M1*. Yau B1*. Taper M1. An Y1. Yeoman C1. Wilson A1. Cattin-Ortolá J2. Maslar D3. Tong J1. Naghiloo S1. Needham E4. Diaz-Vegas A4. Larance M1. Thomas H5. Seidah NG6. von Blume J7. James DE4. Thorn P1. Ailion M2. Asensio C3. Kebede MA1. 1 School of Medical Sciences, Charles Perkins Centre, ...
ORGANISM(S): Rattus rattus (Black rat) 
2024-12-02 | PXD052042 | Pride
Islet Cab45 Insulin 
TranscriptomicsThe probiotic mixture VSL#3 has differential effects on intestinal immune parameters in healthy female BALB/c and C57BL/
Probiotic bacteria may render mice resistant to the development of various inflammatory and infectious diseases. This study aimed to identify underlying mechanisms by which probiotic bacteria may influence intestinal immune homeostasis in non-inflammatory conditions. To this end, we studied the effe...
ORGANISM(S): Mus musculus 
2014-10-23 | E-GEOD-62619 | biostudies-arrayexpress
TranscriptomicsBMT_aGvHD_Intestine
Mice received TBI and allogeneic bone marrow transplantation. One group without and one group with T cells. On day 14 after transplantation mice were sacrificed and the intestinal tract was isolated. RNA was isolated from the intestinal tract of the two experimental groups.
ORGANISM(S): Mus musculus 
2013-01-16 | E-MEXP-3807 | biostudies-arrayexpress
TranscriptomicsSubunit-specific vs. non-selective proteasome modulation in limiting inflammation in experimental colitis
Inflammatory bowel disease (IBD), comprising CrohnM-BM-4s disease and Ulcerative colitis, is characterized by chronic relapsing inflammation of the gut. It has been shown that increased proteasomal activity is associated with the expression of immunoproteasomes, which enhances NF-kB activation and t...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-18163 | biostudies-arrayexpress
MetabolomicsIntegrated gut metabolome and microbiome fingerprinting reveals that dysbiosis precedes allergic inflammation in IgE‐mediated pediatric cow's milk allergy

BACKGROUND: IgE-mediated cow's milk allergy (IgE-CMA) is one of the first allergies to arise in early childhood and may result from exposure to various milk allergens, of which β-lactoglobulin (BLG) and casein are the most important. Understanding the underlying mechanisms behin...

2024-02-15 | MTBLS6768 | MetaboLights
TranscriptomicsComparative transcriptomics and metabolomic analysis of fenofibrate and fish oil treatments in mice
Elevated circulating triglycerides, which are considered a risk factor for cardiovascular disease, can be targeted by treatment with fenofibrate or fish oil. To gain insight into underlying mechanisms, we carried out a comparative transcriptomics and metabolomics analysis of the effect of 2 week tre...
ORGANISM(S): Mus musculus 
2011-10-07 | E-GEOD-32706 | biostudies-arrayexpress
UnknownA fine scale eco-epidemiological study on endemic visceral leishmaniasis in north ethiopian villages.
Not available
S-EPMC5956276 | biostudies-literature
TranscriptomicsThe role of microRNAs in hepatic thyroid hormone signalling
MicroRNAs (miRNAs) are extensively in diverse biological processes. However, very little is known about the role of miRNAs in mediating thyroid hormones (TH) action. Maintenance of appropriate TH levels is known to be critically important for development, differentiation and maintenance of metabolic...
ORGANISM(S): Mus musculus 
2010-08-20 | E-GEOD-21277 | biostudies-arrayexpress
UnknownDapagliflozin in Patients Hospitalized for Heart Failure: Primary Results of the DAPA ACT HF-TIMI 68 Randomized Clinical Trial and Meta-Analysis of Sodium-Glucose Cotransporter-2 Inhibitors in Patients Hospitalized for Heart Failure.
Not available
S-EPMC12910484 | biostudies-literature
TranscriptomicsPulmonary retention of titanium dioxide nanoparticles and biological outcomes following low dose instillation in mice
Pulmonary exposure to high doses of nanoparticles (NP) leads to well characterized lung toxicity in addition to long-term NP retention. However, pulmonary NP accumulation and toxicity following low dose exposures are not well described. In the present study we sought to: (1) investigate particle ret...
ORGANISM(S): Mus musculus 
2013-11-01 | E-GEOD-41041 | biostudies-arrayexpress
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