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TranscriptomicsDifferential production of Type I IFN determines the reciprocal levels of IL-10 and proinflammatory cytokines produced by C57BL/6 and BALB/c macrophages
Pattern recognition receptors (PRR) detect microbial products and induce cytokines which shape the immunological response. Interleukin-12 (IL-12), tumor necrosis factor alpha (TNF-α) and IL-1β are proinflammatory cytokines which can be essential for resistance against infection, but if produced at...
ORGANISM(S): Mus musculus 
2016-09-07 | E-GEOD-79809 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse cystic fibrosis model Cftr knockouts ileum were analysed to investigate intestinal phenotypes
Cystic fibrosis transmembrane conductance regulator (Cftr) knockout mice present the clinical features of low body weight and intestinal disease permitting an assessment of the interrelatedness of these phenotypes in a controlled environment. To identify intestinal alterations which affect body wei...
ORGANISM(S): Mus musculus 
2008-06-14 | E-GEOD-5715 | biostudies-arrayexpress
TranscriptomicsComparative genomic and transcriptomic analysis of Wangiella dermatitidis, a major cause of phaeohyphomycosis and a model black yeast human pathogen
We sequenced mRNA from Wangiella dermatitidis at two pH conditions (2.5 and 6), including three biological replicates of each sample. Examination of transcript level changes in reponse to low pH stress.
ORGANISM(S): Exophiala dermatitidis 
2014-01-27 | E-GEOD-51646 | biostudies-arrayexpress
UnknownCumulative Human Immunodeficiency Virus (HIV)-1 Viremia Is Associated With Increased Risk of Multimorbidity Among US Women With HIV, 1997-2019.
Not available
S-EPMC9897021 | biostudies-literature
MetabolomicsA Python-based pipeline for preprocessing LC-MS data for untargeted metabolomics workflows
Preprocessing data in a reproducible and robust way is one of the current challenges in untargeted metabolomics workflows. Data curation in liquid chromatography-mass spectrometry (LC-MS) involves the removal of unwanted features (retention time; m/z pairs) to retain only high-quality data for subse...
2020-11-21 | MTBLS1919 | MetaboLights
TranscriptomicsTranscription analysis of photocoagulated human retinal pigment epithelial cells in culture
ARPE-19 cells were either laser treated or not, and analyzed 2, 6 and 24 hours after laser treatment. In addition, the cells were treated with high or low glucose (T2D complications analysis). The difference in glucose levels did not make much difference in regards to gene expression. 52 ARPE-19 sam...
ORGANISM(S): Homo sapiens 
2013-10-03 | E-GEOD-41332 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of bleomycin-induced pulmonary fibrosis in mice
Pulmonary fibrosis is a disease characterized by inflammatory cell infiltration, scar formation, deposition of extracellular matrix, alveolar epithelial cell injury and hyperplasia. To determine if alterations in microRNA expression contribute to these phenotypes, microRNA expression profiling of th...
ORGANISM(S): Mus musculus 
2013-09-01 | E-GEOD-45789 | biostudies-arrayexpress
TranscriptomicsCurcumin intake affects miRNA signature in murine melanoma with mmu-miR-205-5p most significantly altered.
Melanoma is the most aggressive form of skin cancer with estimated 48,000 deaths worldwide. The polyphenol curcumin derived from the plant Curcuma longa is well known for its anti-inflammatory and anti-cancerogenic properties. Accordingly, dietary intake of this compound may be suitable for melanoma...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-47211 | biostudies-arrayexpress
TranscriptomicsTranscriptome analysis of CD4+ T cells in experimental autoimmune encephalitomyelitis
In this study we determined whole genome gene expression of murine naive CD4+ T cells, in vitro differentiated Th17 cells, and CD4+ T cells isolated from experimental autoimmune encephalitomyelitis (EAE)-affected animals either after adoptive transfer of Th17 cells or after immunization with MOG35-5...
ORGANISM(S): Mus musculus 
2015-02-26 | E-GEOD-57098 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse embryonic stem cells and primordial germ cells to identify genes up-regulated in pluripotent cells
Understanding the transcriptional regulation of pluripotent cells is of fundamental interest and will greatly inform efforts aimed at directing differentiation of embryonic stem (ES) cells or reprogramming somatic cells. We first analyzed the transcriptional profiles of mouse ES cells and primordial...
ORGANISM(S): Mus musculus 
2007-07-28 | E-MEXP-1158 | biostudies-arrayexpress
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