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Transcriptomicscdr2 siRNA knockdown during passage through mitosis: HeLa cells, Rat1 wild type and c-myc null cells
[Hela cells]: We performed cdr2 knockdown with a pool of 4 cdr2-specific siRNAs to test whether cdr2 may regulate c-myc target genes as cells passage through mitosis. [Rat1a wild type and myc null cells]: We performed cdr2 knockdown using a pool of 4 cdr2-specific siRNAs to test whether cdr2 may r...
ORGANISM(S): Rattus norvegicus 
2010-04-07 | E-GEOD-20037 | biostudies-arrayexpress
TranscriptomicsDEN-induced HCC in c-Met knockout mice
HGF has been reported to have both positive and negative effects on carcinogenesis. Here we show that the loss of c-Met signaling in hepatocytes enhanced rather than suppressed the early stages of chemical hepatocarcinogenesis. c-Met conditional knockout mice (c-metfl/fl, AlbCre+/-; MetLivKO) treate...
ORGANISM(S): Mus musculus 
2008-08-09 | E-GEOD-8747 | biostudies-arrayexpress
Proteomicsc-di-GMP-induced conformational dynamics of the c-di-GMP-binding protein A (CdbA) from Myxococcus xanthus
The second messenger c-di-GMP has important functions in response to changing environmental and cellular cues in bacteria. Here, we report the identification of CdbA, a DNA binding protein of the ribbon-helix-helix family in Myxococcus xanthus, and show that it binds c-di-GMP in vitro. CdbA is essen...
ORGANISM(S): Myxococcus xanthus DK 1622 
2020-04-16 | PXD018028 | Pride
C-di-gmp Plgs Hdx-ms Dynamx 
GenomicsCross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions
Cross-platform Hi-C meta-analysis identifies functional insulators that actively block enhancer-promoter interactions
PRJNA1019713 | ENA
TranscriptomicsATR in C. jejuni
Microarrays were used to identify genes that participate in the acid responce tolerance of C. jejuni. Three biological replicates of two different conditions (pH 5.5 and 7). Two slides and every slide contained three arrays- see attached additional file.
ORGANISM(S): Campylobacter jejuni 
2015-07-01 | E-MEXP-3835 | biostudies-arrayexpress
GenomicsAnalysis of Hybrid Incompatability between C nigoni and C briggsae by mRNA sequencing
Analysis of Hybrid Incompatability between C nigoni and C briggsae by mRNA sequencing
PRJNA306868 | ENA
TranscriptomicsMicroRNA-15/16 Antagonizes c-Myb to Control Natural Killer Cell Maturation (c-Myb overexpression)
NK cells develop in the bone marrow and complete their maturation in peripheral organs, but the molecular events controlling maturation are incompletely understood. Utilizing an NK cell-specific miR-15/16 deficient genetic model (15aKO), we identified a critical role for miR-15/16 family microRNAs i...
ORGANISM(S): Mus musculus 
2015-09-03 | E-GEOD-58268 | biostudies-arrayexpress
Transcriptomics5' Cap-Isolated RNA Pol II Transcripts and ENCODE Tiling Arrays to Identify Gene Expression Changes in Hepatitis C Liver
Recent studies of the human transcriptome suggest that many transcripts have short or lack 3' poly(A) ends. In addition, the length of 3' poly(A) ends may vary for some transcript to regulate mRNA translation. Heterogeneous lengths of poly(A) ends may introduce variations in measuring RNA transcript...
ORGANISM(S): Homo sapiens 
2011-03-29 | E-GEOD-18904 | biostudies-arrayexpress
Transcriptomicsedelfosine and wortmannin effect at 22°c and 4°c-PI4-kinase and phospholipase C signaling in cold response
rs09-04_plc_2 - edelfosine and wortmannin effect at 22°c and 4°c - Is there an overlap between PI4-kinase and phospholipase C signaling in cold response ? - Experiments were carried out with Columbia suspension cells. Cells were treated or not with edelfosine (PLC inhibitor) or wortmannin (PI4-kinas...
ORGANISM(S): Arabidopsis thaliana 
2010-08-01 | E-GEOD-19850 | biostudies-arrayexpress
TranscriptomicsThe Central Role of c-Myc during Malignant Conversion in Human Hepatocarcinogenesis
Hepatocarcinogenesis is a multi-stage process in which precursor lesions progress into early hepatocellular carcinomas (eHCC) by sequential accumulation of multiple genetic and epigenetic alterations. To decode the molecular events during early stages of liver carcinogenesis, we performed gene expre...
ORGANISM(S): Homo sapiens 
2010-05-15 | E-GEOD-12443 | biostudies-arrayexpress
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