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ProteomicsMapping specificity, entropy, allosteric changes and substrates in blood coagulation proteases by a high-throughput protease screen
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-05 | PXD018976 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
ProteomicsHTPS screen of coagulation proteases at 20C with NaCl, ChCl, LiCl
Goal of the experiment is the characterization of proteases activity and specificity upon Na+ binding. Na+ is an allosteric binders that can induce a conformational change of the protease AS to regulate activity and specificity; only proteases with Y and F in position 225 can coordinate a Na+ molecu...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD022959 | Pride
Protease investigation 
ProteomicsN-terminomics profiling of host proteins targeted by excretory-secretory proteases of the nematode Angiostrongylus vasorum identifies points of interaction with canine coagulation and complement cascade
The cardiopulmonary nematode Angiostrongylus vasorum can cause severe disease in dogs, including coagulopathies manifesting with bleeding. We analysed A. vasorum excretory/secretory protein (ESP)-treated dog plasma and serum by N-terminome analysis using Terminal Amine Isotopic Labelling of Substrat...
ORGANISM(S): Angiostrongylus vasorum Canis familiaris (Dog) (Canis lupus familiaris) 
2025-05-07 | PXD056659 | Pride
Dog Serum French heartworm Plasma Tails 
ProteomicsTarget quantification of octapeptide for Thrombin and FX
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD020320 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
ProteomicsSystemic toxicity of snake venom metalloproteinases: proteomics analyses of kidney injury and blood plasma disturbances in a mouse model
Metalloproteinases are abundant in viperid venoms and are implicated in several envenomation effects. Bothrops jararaca venom is reported to induce kidney injury and coagulopathy. HF3 is an extremely hemorrhagic metalloproteinase from B. jararaca venom and participates in the local pathogenesis of e...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2023-01-20 | MSV000091101 | MassIVE
UnknownA plasma proteolysis pathway comprising blood coagulation proteases.
Not available
S-EPMC5173032 | biostudies-literature
UnknownCharacterization of Protein Z-Dependent Protease Inhibitor/Antithrombin Chimeras Provides Insight into the Serpin Specificity of Coagulation Proteases.
Not available
S-EPMC5537704 | biostudies-literature
UnknownParallel imaging of coagulation pathway proteases activated protein C, thrombin, and factor Xa in human plasma.
Not available
S-EPMC9200056 | biostudies-literature
UnknownRoles of Coagulation Proteases and PARs (Protease-Activated Receptors) in Mouse Models of Inflammatory Diseases.
Not available
S-EPMC6310042 | biostudies-literature
ProteomicsQuantitative analysis of design substrates
Proteases are crucial physiologic regulators of protein structure and function. While proteomic methods contributed extensively to protease characterization efforts, technical challenges remain in terms of throughput, scalability and large datasets of protease cleavages remain scarce. Here, we descr...
ORGANISM(S): Homo sapiens (Human) 
2021-02-04 | PXD020321 | Pride
High-throughput protease screen Substrates Blood coagulation proteases Specificity Entropy Allostery 
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