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MetabolomicsAcute response to a high-saturated, high-refined carbohydrate meal in healthy young men shows novel perturbation of multiple metabolic and defense pathways

Regular consumption of fat and refined carbohydrates induces metabolic stress, increasing chronic metabolic disease risk. In healthy volunteers, we characterised the response to a high-fat/high-carbohydrate meal (HFHCM), typical of an ultra-processed food, by proteomic and metabolomics analyses, ...

2026-04-02 | MTBLS10972 | MetaboLights
MetabolomicsIndividual variability in human blood metabolites identifies age-related differences - constant blood metabolite levels during 24h in 4 individuals
Metabolites present in human blood document individual physiological states influenced by genetic, epigenetic, and lifestyle factors. Using high-resolution liquid chromatography-mass spectrometry (LC-MS), we performed nontargeted, quantitative metabolomics analysis in blood of 15 young (29 ± 4 y of ...
2016-03-10 | MTBLS264 | MetaboLights
TranscriptomicsTranscription profiling of human leukocytes to measure the postprandial effect of an oat bran meal on heathy subjects
The goal was to measure the postprandial effect of an oat bran meal on gene expression in leukocytes from healthy subjects and to investigate the postprandial glucose, insulin and triglyceride responses. Linear mixed models were used for the array data to study the simultaneous dependency on many fa...
ORGANISM(S): Homo sapiens 
2010-07-01 | E-MEXP-2261 | biostudies-arrayexpress
MetabolomicsTowards a semi-automated metabolic profile analysis of fish blood plasma by 1H NMR

Aquafeed is one of the main costs in aquaculture and major efforts are being made to find sustainable ingredients that could improve production sustainability and efficiency. Our research focused on the inclusion of glycerol in the feed of European seabass (Dicentrarchus labrax), as it is a cheap...

2022-02-14 | MTBLS1145 | MetaboLights
MetabolomicsOral ketone monoester ingestion reduces circulating blood glucose, exogenous carbohydrate oxidation and oxidation efficiency in trained male cyclists when fed 120 g of CHO per hour during exercise

We examined the effects of ketone monoester (KME) and carbohydrate (CHO) co-ingestion on exogenous CHO oxidation, metabolomic responses and exercise capacity. In a randomised repeated-measures design (after a 36 h CHO loading protocol and pre-exercise meal of 12 and 2 g.kg-1, respectively), eight...

2026-04-22 | MTBLS6260 | MetaboLights
TranscriptomicsTranscription profiling of Anopheles gambiae response to bloodmeal
With their genome sequenced, Anopheles gambiae mosquitoes now serve as a powerful tool for basic research in comparative, evolutionary and developmental biology. The knowledge generated by these studies is expected to reveal molecular targets for novel vector control and pathogen transmission blocki...
ORGANISM(S): Anopheles gambiae 
2008-11-08 | E-GEOD-8822 | biostudies-arrayexpress
ProteomicsShotgun Proteomic Analysis of Proteins Present in Mosquito Ovaries at 24 and 72 h After a Blood Meal
Female mosquitoes require a blood meal for oogenesis, and thereby receive a substantial iron load in the forms of holo-transferrin and hemoglobin. Our previous data showed that during digestion of a blood meal, the gut iron concentration decreases 10-fold, while that of the ovaries doubles from inge...
ORGANISM(S): Aedes aegypti 
2022-03-26 | PXD005893 | Pride
Proteomics Ferritin Aedes aegypti Blood meal Eggs Iron Ovary 
ProteomicsIdentification of molecular response to blood meal in the fatbody of Anopheles stephensi using quantitative proteomics
Fat body is an important tissue in the context of vitellogenesis, vector immunity, vector physiology and vector-parasite interaction. However, the proteome of fatbody and impact of blood meal on the gene expression of this vital organ has not been investigated so far. Therefore, in this study, we ma...
ORGANISM(S): Anopheles stephensi (Asian malaria mosquito) 
2018-01-03 | PXD006462 | Pride
Juvenile hormone and orbitrap fusion mass spectrometer Hemolymph Vitellogenin Egg development 
TranscriptomicsTranscription profiling of human blood cells after high protein and high carbohydrate breakfasts
Our aim was to evaluate the potential of gene expression profiling in blood in a human intervention study investigating the effect of two breakfasts with different macronutrient content on hormonal regulation of satiety. As dietary protein appears to be more satiating than dietary carbohydrate, we t...
ORGANISM(S): Homo sapiens 
2008-08-07 | E-TABM-271 | biostudies-arrayexpress
TranscriptomicsChanges in transcript abundance for cuticular proteins and other genes three hours after a blood meal in Anopheles gambiae.
Numerous studies have examined changes in transcript levels after Anopheles gambiae takes a blood meal. Marinotti et al. (2006) used microarrays and reported massive changes in transcript levels 3 h after feeding (BF3h) compared to non-blood fed (NBF). We were intrigued by the number of transcripts...
ORGANISM(S): Anopheles gambiae 
2014-03-01 | E-GEOD-55453 | biostudies-arrayexpress
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