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GenomicsChIP-seq Accurately Predicts Tissue-Specific Activity of Enhancers
Determining the spatial and temporal activity patterns of enhancers remains a challenge in the functional annotation of the human genome. Here, we performed genome-wide mapping of tissue-specific in vivo binding sites for the enhancer-associated protein p300 and assessed in transgenic mice the util...
ORGANISM(S): Mus musculus 
2009-02-11 | E-GEOD-13845 | biostudies-arrayexpress
GenomicsLarge-Scale Discovery of Enhancers from Human Heart Tissue
Development and function of the human heart depend on the dynamic control of tissue-specific gene expression by distant-acting transcriptional enhancers. While large numbers of heart enhancers have been identified using the mouse as a model system, many of these regulatory sequences are poorly cons...
ORGANISM(S): Mus musculus 
2011-12-04 | E-GEOD-32587 | biostudies-arrayexpress
GenomicsExpanding the Catalog of Enhancer Marks In Vivo
While the majority of protein-coding genes in the human genome have been identified, the location of the regulatory sequences that control their expression in time and space remains poorly defined. The importance of identifying these elements is underscored by a growing number of studies (such as GW...
ORGANISM(S): Mus musculus 
2014-04-16 | E-GEOD-37151 | biostudies-arrayexpress
GenomicsChIP-seq Identification of Weakly Conserved Heart Enhancers
Accurate control of tissue-specific gene expression plays a pivotal role in heart development. However, few cardiac transcriptional enhancers have thus far been identified. Extreme non-coding sequence conservation successfully predicts enhancers active in many tissues, but fails to identify substan...
ORGANISM(S): Mus musculus 
2010-08-22 | E-GEOD-22549 | biostudies-arrayexpress
GenomicsThe Epigenomic Landscape of Prokaryotes
DNA methylation is an important regulator of genome function in the eukaryotes, but it is currently unclear if the same is true in prokaryotes. While regulatory functions have been demonstrated for a small number of bacteria, there have been no large-scale studies of prokaryotic methylomes and the f...
ORGANISM(S): Flexibacter litoralis DSM 6794 
2016-01-20 | E-GEOD-69872 | biostudies-arrayexpress
GenomicsA High-Resolution Enhancer Atlas of the Developing Telencephalon
The mammalian telencephalon plays critical roles in cognition, motor function, and emotion. While many of the genes required for its development have been identified, the distant‐acting regulatory sequences orchestrating their in vivo expression are mostly unknown. Here we describe a digital atlas o...
ORGANISM(S): Homo sapiens 
2013-01-29 | E-GEOD-42881 | biostudies-arrayexpress
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving and treatments with DNA methylation modifying drugs
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine, were subjected to 30 withdrawal days, were treated with aCSF, RG108 or SAM and were subjected to extinction tests. The groups consist of: 1. Rats that self-administered cocaine for 10 days and that were subjected...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66347 | biostudies-arrayexpress
GenomicsRole of PARP1 in cocaine-related memory retrieval
Reward-related memory is an important factor in cocaine seeking. One necessary signaling mechanism for long-term memory formation is the activation of poly(ADP-ribose) polymerase-1 (PARP-1), via poly(ADP-ribosyl)ation. We demonstrate herein that auto-poly(ADP-ribosyl)ation of activated PARP-1 was si...
ORGANISM(S): Rattus norvegicus 
2016-06-25 | E-GEOD-83718 | biostudies-arrayexpress
TranscriptomicsRat DNA methylation in the Nucleus Accumbens in Incubation of Cocaine Craving
DNA methylation profiling of nucleus Accumbens of rats that self administered cocaine and were subjected to 1 or 30 withdrawal days with or without extinction tests. The groups consist of 1. Saline rats (Sal.) 2. Rats that self-administered cocaine for 10 days and that were subjected to a withdrawal...
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66348 | biostudies-arrayexpress
TranscriptomicsRole of DNA Methylation in the Nucleus Accumbens in Incubation of Cocaine Craving
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Rattus norvegicus 
2015-02-27 | E-GEOD-66350 | biostudies-arrayexpress
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