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ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 - Interaction Proteomics of FBXO31 in HEK293T cells
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Immunoprecipitation followed by MS (IP-MS) was performed on HA-tagged cDNA-expressed var...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055535 | Pride
Ap-ms Fbxo31 Ip-ms Oxidative stress Ubiquitin ligase 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 – Expression Proteomics
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. FBXO31(D334N) is a dominant de novo mutation found among patients with cerebral palsy. T...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055818 | Pride
Tmt Ubiquitin ligase Fbxo31 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31 – CTAP discovery
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. CTAPs can arise from internal protein cleavage events during which the N-terminal fragme...
ORGANISM(S): Homo sapiens (Human) 
2024-11-05 | PXD055814 | Pride
C-terminal amide Oxidative stress Ubiquitin ligase Fbxo31 
ProteomicsC-terminal amides mark proteins for degradation via SCF/FBXO31
FBXO31 is a substrate adapter for the SCF-type ubiquitin ligase complex SCF/FBXO31 which ubiquitylates C-terminal amide-bearing proteins (CTAPs), thereby triggering their proteasomal degradation in human cells. Profiling of active cullin-RING ubiquitin E3 ligases was performed in naive or FBXO31 kno...
ORGANISM(S): Homo sapiens (Human) 
2024-11-07 | PXD055518 | Pride
Ligase Cullin Fbxo31 Ring Scf Ubiquitin E3 
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