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TranscriptomicsSTAT3 expression, activity and functional consequences of STAT3 inhibition in esophageal squamous cell carcinomas and BarrettM-bM-^@M-^Ys adenocarcinomas
Signal transducer and activator of transcription 3 (STAT3) is altered in several epithelial cancers and represents a potential therapeutic target. Here, STAT3 expression, activity and cellular functions were examined in two main histotypes of esophageal carcinomas. In situ, immunohistochemistry for ...
ORGANISM(S): Homo sapiens 
2013-06-16 | E-GEOD-47763 | biostudies-arrayexpress
TranscriptomicsB-Raf inhibitors induce epithelial differentiation in BRAF mutant colorectal cancer cells
Mutations in the BRAF proto-oncogene, which encodes the B-Raf kinase, are associated with more aggressive, less-differentiated and therapy-resistant colorectal cancers (CRC). However, the molecular mechanisms responsible for these correlations remain unknown. Here, we report the characterization of ...
ORGANISM(S): Homo sapiens 
2014-12-21 | E-GEOD-50791 | biostudies-arrayexpress
MetabolomicsCXCL12 and MYC control energy metabolism to support adaptive responses after kidney injury
Kidney injury is a common complication of severe disease. Here, we report that injuries of the zebrafish embryonal kidney are rapidly repaired by a migratory response in 2-, but not in 1-day-old embryos. Gene expression profiles between these two developmental stages identify cxcl12a and myca as can...
2018-10-11 | MTBLS723 | MetaboLights
TranscriptomicsTranscription profiling by array of miRNA in mouse models of melanoma comparing niches of tumour tissue to adjacent normal tissue
This experiment focused on the miRNA expressions within the tissues specific niches of mice afflicted with melanoma, compared to littermates without malignancy. BRafCA/ PtenloxP/ Tyr::CreERT2 or genetically matched littermates without Cre recombinase were treated with 2µl 4-hydroxytamoxifen (5mM), e...
ORGANISM(S): Mus musculus 
2019-01-31 | E-MTAB-6373 | biostudies-arrayexpress
TranscriptomicsExpression via microarray of total RNA isolated from B16 murine melanoma cells stimulated with Interferon-gamma versus untreated controls.
Functional in vitro studies revealed changes in B16 melanoma migration and proliferation when exposed to Interferon-gamma.
ORGANISM(S): Mus musculus 
2019-01-31 | E-MTAB-6372 | biostudies-arrayexpress
TranscriptomicsRocaglamide selectively inhibits the G1-S-phase transition in cancer cells by activation of the ATM/ATR-mediated Chk1/2 cell cycle checkpoints
The cell division cycle is tightly controlled in normal cells. Cancer cells are characterized by deregulation in cell division cycle, which is associated with increased DNA replication and elevated cellular proliferation. Recently, genetic studies indicate that cyclin dependent kinases CDK2, CDK4 an...
ORGANISM(S): Homo sapiens 
2013-10-12 | E-GEOD-41072 | biostudies-arrayexpress
TranscriptomicsERN1 and ALPK1 inhibit differentiation of bi-potential tumor-initiating cells in human breast cancer
Cancers are heterogeneous by nature. While traditional oncology screens commonly use a single endpoint of cell viability, altering the phenotype of tumor-initiating cells may reveal alternative targets that regulate cellular growth by processes other than apoptosis or cell division. We evaluated the...
ORGANISM(S): Homo sapiens 
2016-10-27 | E-GEOD-79630 | biostudies-arrayexpress
TranscriptomicsMolecular fingerprint of the podocyte reveals novel gene regulatory networks
The thorough characterization of the transcriptome of endogenous podocytes has been hampered by low yields of cell isolation procedures. Here we introduce a double fluorescent reporter mouse model combined with an optimized bead perfusion protocol and efficient single cell dissociation yield...
ORGANISM(S): Mus musculus 
2012-11-30 | E-GEOD-39441 | biostudies-arrayexpress
TranscriptomicsModeling the time resolved transcriptional signature of time sequential stimulation with HGF and IL-6 in hepatocyte proliferation
Liver regeneration is characterized by a scheduled sequence of inner and intra-cellular signaling events. It starts with an initial inflammatory phase, followed by a period of rapidly proliferating hepatocytes and stopping abruptly when the liver mass is restored. The cytokines hepatocellular growth...
ORGANISM(S): Mus musculus 
2016-06-01 | E-GEOD-69935 | biostudies-arrayexpress
TranscriptomicsBoolean modeling reveals the necessity of transcriptional regulation for bistablity in PC12 Cell Differentiation
The nerve growth factor NGF has been shown to cause cell fate decisions towards either differentiation or proliferation depending on the relative activity of downstream pERK, pAKT or pJNK signaling. However, how these protein signals are translated into and fed back from transcriptional activity to ...
ORGANISM(S): Rattus norvegicus 
2016-03-23 | E-GEOD-74327 | biostudies-arrayexpress
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