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TranscriptomicsKnockdown of Zona Pellucida protein 2 (ZP2) in mouse embryos by Trim-away and morpholino combined
The zona pellucida (Zp) genes are quintessential oocyte-specific genes that are transcribed only during oogenesis and whose protein products are secreted in the extracellular space. In mice the Zp genes are three: Zp1, Zp2, Zp3 (Zp4 is a pseudogene). Contrary to longtime knowledge, data from 2023 ha...
ORGANISM(S): Mus musculus 
2025-12-19 | E-MTAB-16339 | biostudies-arrayexpress
TranscriptomicsObjective molecular criteria for oocyte quality and developmental potential: a proteomic study in inbred mice
Current understanding of oocyte quality and developmental potential maintains that stochastic or epigenetic processes modulate the action of determinants that are laid in the oocyte during oogenesis. These determinants are considered to be rather conserved across mice, leading different strains of m...
ORGANISM(S): Mus musculus 
2016-06-18 | E-MTAB-5013 | biostudies-arrayexpress
TranscriptomicsMaternal age effect on mouse oocytes: new biological insight from proteomic analysis
The long-standing view of 'immortal germ line versus mortal soma' poses a fundamental question in biology concerning how oocytes age in molecular terms. A mainstream hypothesis is that maternal aging of oocytes has its roots in gene transcription. Investigating the proteins resulting from mRNA trans...
ORGANISM(S): Mus musculus 
2014-04-15 | E-GEOD-42959 | biostudies-arrayexpress
TranscriptomicsTranscriptional profiling of mouse SCNT and ICSI eight-cell embryos with different developmental timings
To gain insight if developmental timings of early embryonic cleavages relate to systematic gene expression differences
ORGANISM(S): Mus musculus 
2011-10-31 | E-TABM-1182 | biostudies-arrayexpress
TranscriptomicsReprogramming of two somatic nuclei in the same ooplasm leads to pluripotent embryonic stem cells
We provide proof that the oocyte is able to reprogram two somatic nuclei at once and therefore is not limited in its reprogramming capacity to a single nucleus. Mouse ooplasts transplanted with 2 somatic cell nuclei simultaneously (double nuclear transfer) support preimplantation development and the...
ORGANISM(S): Mus musculus 
2013-07-11 | E-GEOD-36468 | biostudies-arrayexpress
TranscriptomicsHuman ART culture conditions prime mouse embryos for postimplantation development
With the increasing use of Assisted Reproductive Technologies (ART) for treatment of human infertility, there is an increasing requirement for embryo culture conditions that perform as similar to nature as possible. How good the match, however, cannot be tested experimentally in human. We solved th...
ORGANISM(S): Mus musculus 
2012-05-02 | E-GEOD-31414 | biostudies-arrayexpress
TranscriptomicsSomatic cell nuclear reprogramming by mouse oocytes endures beyond reproductive decline
The mammalian oocyte has the unique feature of supporting fertilization and normal development while being able of reprogramming the nuclei of somatic cells towards pluripotency and occasionally even totipotency. Whilst oocyte quality is known to decay with somatic aging it is not a given that diffe...
ORGANISM(S): Mus musculus 
2011-08-15 | E-GEOD-23654 | biostudies-arrayexpress
TranscriptomicsARTs versus developmental plasticity: blastocyst abnormalities after ICSI and embryo culture do not propagate into the offspring in mice
Following intracytoplasmic sperm injection (ICSI), in vitro culture (IVC) in ART media causes imbalance in the blastocyst's inner cell mass (ICM)with reduction of the primitive endoderm compartment compared to non-IVC blastocystsFollowing embryo transfer (ET), these imbalances do not influence birth...
ORGANISM(S): Mus musculus 
2016-08-25 | E-GEOD-50193 | biostudies-arrayexpress
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