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Allergen-bearing extracellular nanovesicles, termed “pollensomes”, are released by pollen during germination. These extracellular vesicles (EVs) may play an important role in pollen-pistil interaction during fertilization, stabilizing the secreted bioactive molecules and allowing long-distance signa...
ORGANISM(S): Actinidia chinensis 
2023-01-23 | PXD039037 | Pride
Increased export of transglutaminase-2 (TG2) by tubular epithelial cells (TECs) into the surrounding interstitium modifies the extracellular homeostatic balance leading to fibrotic membrane expansion. Although silencing of extracellular TG2 ameliorates progressive kidney scarring in animal models of...
ORGANISM(S): Mus musculus (Mouse) 
2018-02-07 | PXD008173 | Pride
Endoplasmic reticulum (ER) stress plays an important role in pancreatic β-cell 20 dysfunction and death, contributing to both type 1 and type 2 diabetes. The Unfolded 21 Protein Response (UPR) is a key adaptive mechanism that helps cells cope with ER 22 stress by altering gene expression. RNA-bindin...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-29 | PXD066750 | Pride
This study provides insights into the efficacy of beta-blockers as breast cancer therapeutics.Cell line models of basal-type and estrogen receptor-positive breast cancer were profiled for basal levels of adrenoceptor gene/protein expression, and ADRβ2-mediated cell behaviour including migration, inv...
ORGANISM(S): Homo sapiens (Human) 
2020-05-26 | PXD009488 | Pride
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