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ProteomicsProteomic Profiles of Human Arterioles Isolated from Fresh Adipose Tissue or Following Overnight Storage
Arterioles are key determinants of the total peripheral vascular resistance, which, in turn, is a key determinant of arterial blood pressure. However, the amount of protein available from one isolated human arteriole may be less than 5µg, making proteomic analysis challenging. In addition, obtaining...
ORGANISM(S): Homo sapiens (Human) 
2024-03-21 | PXD044454 | Pride
Arterioles Tmt labeled mass spectrometry Booster channel Overnight storage Proteomics 
TranscriptomicsIdentification of the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans
Microarray analysis was used to identify the calcium-responsive genes dependent on CrzA in the filamentous fungus Aspergillus nidulans. In order to identify such genes, we conducted the two types of experiment. One was a comparison between wild type with calcium treatment and wild type without cal...
ORGANISM(S): Emericella nidulans 
2008-10-02 | E-GEOD-12953 | biostudies-arrayexpress
TranscriptomicsIdentification of osmotic stress-responsive genes dependent on HogA and AtfA in Aspergillus nidulans
Microarray analysis was used to identify the osmotic stress-responsive genes dependent on HogA and AtfA in the filamentous fungus Aspergillus nidulans. In order to identify such genes, we conducted the several types of experiment. One was a comparison between wild type with and without osmotic sho...
ORGANISM(S): Emericella nidulans 
2009-06-15 | E-GEOD-16566 | biostudies-arrayexpress
ProteomicsDistinct types of intramitochondrial protein aggregates protect mitochondria against proteotoxic stress - Data Set5: TMT dataset of aggregates in mitochondria
Mitochondria consist of hundreds of proteins, most of which are long-lived and inaccessible to the proteasomal quality control system of the cytosol. How cells stabilize the mitochondrial proteome during challenging conditions is poorly understood. Here we show that mitochondria form spatially defin...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2024-03-26 | PXD048691 | Pride
Mitochondria aggregates 
ProteomicsQuantitative Single-Cell Proteomics as a Tool to Characterize Cellular Hierarchies
Large-scale single-cell analyses are of fundamental importance in order to capture biological heterogeneity within complex cell systems, but have largely been limited to RNA-based technologies. Here we present a comprehensive benchmarked experimental and computational workflow, which establishes glo...
ORGANISM(S): Homo sapiens (Human) 
2021-05-06 | PXD020586 | Pride
Tmtpro Lc-ms Single cell proteomics Scms 
ProteomicsProteomics of SARS-CoV and SARS-CoV-2 infected cells
The pandemic of the novel Coronavirus SARS-CoV-2, cause of Covid-19, has caused tens of thousands of deaths since its emergence in late 2019. An in-depth knowledge of the molecular biology of the virus infection is key for a better understanding of the virus and the progression of the disease. We he...
ORGANISM(S): Homo sapiens (Human) 
2020-04-24 | PXD018581 | Pride
Covid19 Sars-cov Tmt Sars-cov-2 Phosphoproteomics 
ProteomicsNeurofibromatosis type 1-dependent alterations in mouse microglia function are not cell-intrinsic
We previously discovered a sex-by-genotype defect in microglia function using a germline heterozygous knockout mouse model of Neurofibromatosis type 1 (Nf1+/- mice), in which only microglia from male Nf1+/- mice exhibited defects in purinergic signaling. Herein, we leveraged an unbiased proteomic ap...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD035881 | Pride
Purinergic signaling Sex differences Neurofibromin Nf1 Cortex Microglia Genetically engineered mice 
TranscriptomicsTranscriptome partitioning in mouse fertilization.
RNA transcripts are distributed non-uniformly in the oocytes of many animals, such that newly-divided embryo cells (blastomeres) inherit distinct transcriptomes following fertilization. In animals such as the frog, Xenopus laevis, programmed transcript regionalization directs early embryonic axis fo...
ORGANISM(S): Mus musculus 
2011-04-21 | E-GEOD-27396 | biostudies-arrayexpress
ProteomicsDivergent Antibody Repertoires Found for Omicron versus Wuhan SARS-CoV-2 Strains using Ig-MS
SARS-CoV-2 Omicron (B.1.1.529) and its subvariants are currently the most common variants of concern worldwide, featuring numerous mutations in the spike protein and elsewhere that collectively make Omicron more transmissible and more resistant to antibody-mediated neutralization provided by vaccina...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-08-24 | MSV000090199 | MassIVE
UnknownChloride intracellular channel 1 activity is not required for glioblastoma development but its inhibition dictates glioma stem cell responsivity to novel biguanide derivatives.
Not available
S-EPMC8822754 | biostudies-literature
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