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ProteomicsProteome mapping of human gingival tissue in health and disease
Gingival tissue proteome is at the forefront of the periodontal research, yet have been hampered by lack of sufficient tissue-extraction methods. Using an emerging technology for tissue homogenization, pressure cycling technology (PCT), we characterize the gingival tissue proteomic profiles of both ...
ORGANISM(S): Homo sapiens (Human) 
2020-09-25 | PXD018029 | Pride
Pressure cycling technology Gingival tissue proteome Chronic periodontitis 
ProteomicsA. aphrophilus uses a type VI secretion system to modify epithelial cell responses to highly leukotoxic A. actinomycetemcomitans
The Type VI secretion system (T6SS) is a bacterial mechanism that delivers effectors to eliminate competitors and modulate host responses. We previously discovered that the oral symbiont Aggregatibacter aphrophilus uses its T6SS to kill the pathobiont Aggregatibacter actinomycetemcomitans. To unders...
ORGANISM(S): Homo sapiens (Human) 
2025-11-10 | PXD057672 | Pride
A. aphrophilus A. actinomycetemcomitans T6ss 
ProteomicsProbing the Salivary Proteome for Prognostic Biomarkers in Response to Non-Surgical Management of Periodontitis
This prospective study aimed to investigate salivary proteome changes in periodontitis patients in response to treatment. Ten systemically healthy, non-smokers with stage III, grade C periodontitis (32-43yrs, F:M:5:5) underwent non-surgical periodontal treatment. Saliva (n=30) was collected pre- (T0...
ORGANISM(S): Homo sapiens (Human) 
2024-06-10 | PXD043901 | Pride
Label-free quantitative proteomics Periodontal treatment Biomarkers Saliva Periodontitis 
ProteomicsComparative Proteomic Signatures in Periodontitis: Saliva, Gingival Crevicular Fluid (GCF), Plaque, vs. Serum
Saliva, gingival crevicular fluid (GCF), and serum are common sources for studying host response and oral microbiota in periodontal patients. This cross-sectional study aimed to compare the proteomic signatures of periodontitis patients using full-mouth periodontal sampling with those obtained from...
ORGANISM(S): Homo sapiens (Human) 
2025-10-27 | PXD055509 | Pride
Gcf Serum Saliva Periodontitis 
ProteomicsGingival exudatome dynamics implicates inhibition of the alternative complement pathway in the protective action of the C3 inhibitor Cp40 in non-human primate periodontitis
Complement inhibition has been successfully used to treat periodontitis in animal models. However, proteome studies that investigated the role of complement C3 were missing. The objective of this study was to characterize local tissue exudate (“gingival crevicular fluid”; GCF) changes after administ...
ORGANISM(S): Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) 
2018-08-17 | PXD009502 | Pride
C3 inhibitor Gcf Periodontitis Macaca fascicularis 
ProteomicsSubgingival Proteome In Parents With Periodontitis And Their Offspring
This study evaluated the subgingival proteome of parents with periodontitis and their offspring, thereby assessing signatures of periodontal disease. Forty participants were allocated into four groups (n = 10 per group): parents with periodontitis (PP) and their offspring (CP), and control parents (...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD064469 | Pride
Dia-pasef Lc-msms Periodontitis 
ProteomicsBacterial symbionts use a type VI secretion system for fitness increase against pathobionts
The Type VI Secretion System (T6SS) in bacteria is a versatile mechanism that facilitates protein transport into neighboring cells and can act as an antibacterial weapon by eliminating competing organisms in the vicinity. The objective of this study was to characterize the T6SS in Aggregatibacter ap...
ORGANISM(S): Candida albicans (Yeast) Streptococcus mutans Aggregatibacter aphrophilus Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum subsp. nucleatum Veillonella dispar Actinomyces oris 
2024-05-24 | PXD042723 | Pride
Aggregatibacter actinomycetemcomitans T6ss Aggregatibacter aphrophilus 
ProteomicsHistone-like family of nucleoid structuring protein of A. actinomycetemcomitans promotes biofilm formation and alters protein dynamics of other species within multi-species biofilm
Aggregatibacter actinomycetemcomitans is a Gram-negative organism, strongly associated with aggressive forms of periodontitis. An important virulence property of A. actinomycetemcomitans is its ability to form tenacious biofilms that can attach to abiotic as well as biotic surfaces. The histone-like...
ORGANISM(S): Candida albicans (Yeast) Aggregatibacter aphrophilus Streptococcus mutans Streptococcus oralis Aggregatibacter actinomycetemcomitans (Actinobacillus actinomycetemcomitans) (Haemophilus actinomycetemcomitans) Fusobacterium nucleatum Veillonella dispar Actinomyces oris 
2018-06-05 | PXD008444 | Pride
Multi-species biofilm Hns A. actinomycetemcomitans Label-free quantification 
UnknownTREM-1 Pathway Biomarkers for Classification of Periodontal Diseases and Monitoring of Treatment Response in Grade B and C Periodontitis.
Not available
S-EPMC12377945 | biostudies-literature
UnknownNovel and known periodontal pathogens residing in gingival crevicular fluid are associated with rheumatoid arthritis.
Not available
S-EPMC8048861 | biostudies-literature
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