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TranscriptomicsTranscription profiling by array of siRNA transfected HEK293T cells untreated or treated with TNF-alpha to study the effect of siRNA-mediated knockdown of different genes
HEK293T cells were treated with TNF-alpha for different periods of time to study the effect of siRNA-mediated knockdown of different genes (negative control: Renilla luciferase; positive controls: TNFRSF1A, RelA; gene of interest: CASP4) on TNF-induced gene expression
ORGANISM(S): Homo sapiens 
2012-07-06 | E-MTAB-900 | biostudies-arrayexpress
ProteomicsCLDN3 in prostate cancer exosomes
Exosomes are an emerging source for biomarkers in various diseases. Prostate cancer is the most frequent cancer in men in industrialized countries. The only biomarker widely used is prostate specific antigen with its clinical relevance suffering from low specificity. To identify novel biomarker cand...
ORGANISM(S): Bos taurus (Bovine) Homo sapiens (Human) 
2017-04-13 | PXD003651 | Pride
Claudin3 Mass spectrometry Exosomes Prostate cancer 
TranscriptomicsRNA-Seq of Drosophila cell line Dmel2
Deep Sequencing of mRNA from the Drosophila melanogaster cell line D.Mel-2 Analysis of poly(A)+ RNA of D.Mel-2 cell line
ORGANISM(S): Drosophila melanogaster 
2010-04-09 | E-GEOD-21283 | biostudies-arrayexpress
TranscriptomicsRNAseq transcriptomic signature associated depletion of Evi/Wls in epidermal sheets of mice, expression analysis of epidermal sheets of Evi/Wls knockout and wildtype mice
Evi/Wls is an essential Wnt secretion factor and important for tissue homeostasis. In the skin Wnt signaling plays an important role in hair follicle formation and maintenance. The aim of the present study is to compare the gene expression profile of Evi/Wls knockout epidermal sheets with wild-type ...
ORGANISM(S): Mus musculus 
2013-07-24 | E-MTAB-1613 | biostudies-arrayexpress
TranscriptomicsWnt secretion protein Evi/Gpr177 promotes glioma tumorigenesis
Silencing of Evi and beta-catenin in U87MG cells
ORGANISM(S): Homo sapiens 
2012-06-29 | E-MTAB-776 | biostudies-arrayexpress
UnknownEnhancing knowledge discovery from cancer genomics data with Galaxy.
Not available
S-EPMC5437943 | biostudies-literature
TranscriptomicsSIN3A-regulated LIF-responsive genes in MCF7 cells
Tyrosine phosphorylation is a hallmark for activation of Signal Transducer and Activator of Transcription (STAT) proteins, but their transcriptional activity also depends on other secondary modifications. Type I interferons (IFNs) can activate both the ISGF3 (STAT1:STAT2:IRF9) complex and STAT3, but...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-35696 | biostudies-arrayexpress
ProteomicsRegulatory role of E3 ubiquitin ligase Smurf2 on transcriptional corepressor KAP1
An E3 ubiquitin ligase Smurf2 and transcriptional co-repressor KAP1 have been documented to play crucial roles in similar cellular pathways including cell cycle, DNA damage response, chromatin compaction, senescence and cell death. Smurf2 and KAP1, through regulation of these cellular processes eith...
ORGANISM(S): Homo sapiens (Human) 
2022-04-07 | PXD029642 | Pride
Human Kap1 E3 ubiquitin ligase Ubiquitination Smurf2 
TranscriptomicsThe head-regeneration transcriptome of the planarian Schmidtea mediterranea
The head-regeneration transcriptome of the planarian Schmidtea mediterranea
ORGANISM(S): Schmidtea mediterranea 
2011-07-15 | E-MTAB-607 | biostudies-arrayexpress
TranscriptomicsRNAi of signal transduction components in HCT116 cells
We performed RNAi knockdown experiments on 7 different signal transduction components of the Wnt pathway in HCT116 colon cancer cells and prepared RNA libraries from the poly-adenylated fraction of the RNA. SOLiD sequencing of strand-specific, barcoded transcriptome libraries yielded expression prof...
ORGANISM(S): Homo sapiens 
2014-04-18 | E-MTAB-651 | biostudies-arrayexpress
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