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MetabolomicsInhibition of glycolysis and mitochondrial respiration promotes radiosensitisation of neuroblastoma and glioma cells

BACKGROUND: Neuroblastoma accounts for 7% of paediatric malignancies but is responsible for 15% of all childhood cancer deaths. Despite rigorous treatment involving chemotherapy, surgery, radiotherapy and immunotherapy, the 5-year overall survival rate of high-risk disease remai...

2022-11-30 | MTBLS858 | MetaboLights
ProteomicsHendra virus infection of bat (Pteropus alecto) and human cells
SILAC labeled human kidney cells (293 cells) or bat kidney cells (PakiT03cells)were infected with Hendra virus for 8 or 24 hours and compared to uninfected control cells. Protein identification and quantitation relied on a combination of Uniprot lists of proteins and Proteomics Informed by Transcrip...
ORGANISM(S): Pteropus alecto (Black flying fox) Homo sapiens (Human) Hendra virus (isolate Horse/Autralia/Hendra/1994) 
2014-11-05 | PXD001165 | Pride
Human pteropus alecto hendra virus orbitrap velos 
UnknownIntravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.
Not available
S-EPMC5648171 | biostudies-literature
UnknownIDOL regulates systemic energy balance through control of neuronal VLDLR expression.
Not available
S-EPMC7028310 | biostudies-literature
MetabolomicsAntibacterial Monoclonal Antibodies Do Not Disrupt the Intestinal Microbiome or Its Function
Antibiotics revolutionized medicine, however, it is now clear that broad-spectrum antibiotics alter the composition and function of the host’s microbiome. The microbiome plays a key role in human health and its perturbation is increasingly recognized as contributing to many human diseases. Wide spre...
2021-01-11 | MTBLS1257 | MetaboLights
UnknownSHARING Choices: A Pilot Study to Engage Family in Advance Care Planning of Older Adults With and Without Cognitive Impairment in the Primary Care Context.
Not available
S-EPMC8206219 | biostudies-literature
UnknownEpstein-Barr virus-associated post-transplant lymphoproliferative disorders in pediatric transplantation: A prospective multicenter study in the United States.
Not available
S-EPMC11115376 | biostudies-literature
TranscriptomicsFunctional Plasticity of Regulatory T Cell Function
Regulatory T cells (Tregs) can suppress a wide variety of cell types, in diverse organ sites and inflammatory conditions. While Tregs possess multiple suppressive mechanisms, the number required for maximal function is unclear. Furthermore, whether any inter-relationship orcross-regulatory mechani...
ORGANISM(S): Mus musculus 
2011-12-08 | E-GEOD-29262 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of livers of C57BL/6 mice and LDL receptor deficient mice fed on either low fat or high fat diet to study liver gene expression associated with diet.
Examination of gene expression profiles from liver of C57BL/6 mice and LDL receptor deficient mice fed on either a low fat diet or a high fat Western-style diet for 12 weeks. Three replicates of each condition analyzed. Keywords = LDL receptor deficiency, high fat diet, atherosclerosis, liver
ORGANISM(S): Mus musculus 
2007-11-01 | E-GEOD-363 | biostudies-arrayexpress
ProteomicsIdentification of novel pyrazolopyrimidine compounds that modulate the shelterin complex and telomere length regulation via phosphoglycerate kinase 1 and stress sensor DJ1
Telomere signalling and metabolic dysfunction are hallmarks of cell aging, and are associated with a variety of pathologies. Identification of new agents targeting these processes might provide therapeutic opportunities, including chemoprevention strategies against cancer predisposition. Here we rep...
ORGANISM(S): Homo sapiens (Human) 
2019-07-19 | PXD011356 | Pride
Trf2 Shelterin Dj1 Pgk1 Telomere Stress 
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