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TranscriptomicsRNA-seq of hepatocytes obtained through step-wise differentiation of hIPSCs from a patient with A1AT deficiency and its point mutation-corrected isogenic hIPSC line. Comparison to primary hepatocytes from a healthy donor and an A1AT-deficient patient.
A1AT deficiency is an autosomal not recessive disorder caused by mutations in the SERPINA1 gene. Individuals with the Z variant retain polymerised protein in the endoplasmic reticulum of hepatocytes, predisposing them to liver disease. This study primarily aimed to uncover the molecular mechanisms t...
ORGANISM(S): Homo sapiens 
2018-06-26 | E-MTAB-6781 | biostudies-arrayexpress
UnknownFeral swine as sources of fecal contamination in recreational waters.
Not available
S-EPMC7893155 | biostudies-literature
TranscriptomicsTranscription profiling of field-caught permethrin-resistant Anopheles gambiae shows over-expression of CYP6P3, a P450 that metabolizes pyrethroids
Field-caught permethrin-resistant Anopheles gambiae s.s. overexpress CYP6P3, a P450 that metabolizes pyrethroids
ORGANISM(S): Anopheles gambiae s.s. 
2009-01-17 | E-MTAB-52 | biostudies-arrayexpress
ProteomicsD vulgaris WT-IPFG07 chemostat comparison
Parallel chemostats of Desulfovibrio vulgaris Hildenborough WT and IPFG07 (DsrC low-expression) mutant were sampled over 5 turnovers at steady-state. Extracted proteins were digested with trypsin and peptides were isotopically labeled for quantification using the diDO-IPTL methodology (Waldbauer et ...
ORGANISM(S): Desulfovibrio Vulgaris Str. Hildenborough (ncbitaxon:882) 
2018-11-26 | MSV000083165 | MassIVE
UnknownStrongly regulated transcription factors exert an outsized influence in microRNA-regulated networks.
Not available
S-EPMC12853912 | biostudies-literature
ProteomicsThe fitness cost of spurious phosphorylation
The fidelity of signal transmission requires the binding of regulatory molecules to their cognate targets. However, the crowded cell interior risks off-target interactions between proteins that are functionally unrelated. Understanding the constraints this imposes on cell systems evolution requires ...
ORGANISM(S): Homo sapiens (Human) Saccharomyces cerevisiae (Baker's yeast) 
2024-09-12 | PXD045466 | Pride
Spurious Human Lcms Phosphotyrosine Yeast 
TranscriptomicsTranscription profiling of mouse in vitro reprogrammed fibroblasts carrying retroviral transgenes for Oct4, Sox2, Klf4, and c-Myc to investigate developmental potential
Comparison of in vitro reprogrammed fibroblasts carrying retroviral transgenes for Oct4, Sox2, Klf4, and c-Myc with non-infected fibroblasts and wt ES cells.
ORGANISM(S): Mus musculus 
2007-06-06 | E-MEXP-1037 | biostudies-arrayexpress
GenomicsDAC for study SEQCAP Analysis Of Genomic Integrity Of Disease Corrected Human Pluripotent Stem Cells
Data Access Committee EGAC00001000021
EGAC00001000021 | EGA
UnknownDissection of the role of a Src homology 3 domain in the evolution of binding preference of paralogous proteins.
Not available
S-EPMC10763533 | biostudies-literature
UnknownHyperphosphatemia Contributes to Skeletal Muscle Atrophy in Mice.
Not available
S-EPMC11395169 | biostudies-literature
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