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MetabolomicsGlycolysis/gluconeogenesis specialization in microbes is driven by biochemical constraints of flux sensing
Central carbon metabolism is highly conserved across microbial species, but can catalyze very different pathways depending on the organism and their ecological niche. Here, we study the dynamic reorganization of central metabolism after switches between the two major opposing pathway configurations ...
2022-01-11 | MTBLS3887 | MetaboLights
ProteomicsTYK2 inhibition reverses immune-mediated neural cell death triggered by cytoplasmic dsRNA, a damage associated molecular pattern present in Alzheimer’s Disease
Neuroinflammation is a pathological feature of distinct neurodegenerative diseases, including Alzheimer’s disease (AD) and ALS, raising the possibility of common therapeutic targets. We previously established that cytoplasmic double-stranded RNA (cdsRNA) is spatially coincident with cytoplasmic pTDP...
ORGANISM(S): Homo sapiens (Human) 
2025-12-09 | PXD043641 | Pride
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Homo sapiens (Human) 
2025-07-14 | PXD048282 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
ProteomicsTRPV2 ion channel interactome reveals functional interaction with NCAM and L1CAM in neurite outgrowth
TRPV2 voltage-insensitive, calcium-permeable ion channels play important roles in cancer progression, immune response, and neuronal development. Despite TRPV2’s physiological impact, underlying endogenous proteins mediating TRPV2 responses and affected signaling pathways remain elusive. Using quanti...
ORGANISM(S): Rattus norvegicus (Rat) 
2025-07-14 | PXD048260 | Pride
Neurite outgrowth Trpv2 Neural cell adhesion molecule (ncam) L1cam 
ProteomicsATM Inhibition Exploits Checkpoint Defects and ATM-Dependent Double Strand Break Repair in TP53-Mutant Glioblastoma
Determining the balance between DNA double strand break repair (DSBR) pathways is essential for understanding treatment response in cancer. We report a novel method for simultaneously measuring non-homologous end joining (NHEJ), homologous recombination (HR), and microhomology-mediated end joining (...
ORGANISM(S): Homo sapiens (Human) 
2024-03-08 | PXD047837 | Pride
Dna double strand break repair Tp53-mutant glioblastoma Atm inhibition 
ProteomicsFight-or-flight responses require augmentation of Ca2+ influx via Rad phosphorylation
Fight-or-flight responses involve β-adrenergic-induced increases in heart rate and contractile force. Despite decades of investigations, predominantly focusing on ryanodine receptor and phospholamban phosphorylation, the molecular mechanisms underlying the sympathetic nervous system control of cardi...
ORGANISM(S): Mus musculus (Mouse) 
2022-09-26 | PXD033492 | Pride
Contractility Heart Mass spectrometry Adrenergic Calcium Phosphorylation Pka Phosphatases Ion channels 
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