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TranscriptomicsCulture induced changes in Blood-Brain Barrier transcriptome: implications for amino acid transporters in vivo
Tight homeostatic control of brain amino acids (AA) depends on transport via solute family carrier proteins expressed by the Blood-Brain Barrier (BBB) microvascular endothelial cells (BMEC). To characterize the mouse BMEC transcriptome and probe culture-induced changes microarray analyses of PECAM-1...
ORGANISM(S): Mus musculus 
2010-05-18 | E-GEOD-14375 | biostudies-arrayexpress
TranscriptomicsTranscruption profiling of human cerebellum, frontal cortex [BA4, BA9] and caudate nucleus HD tissue experiment
Post mortem human brain tissue comparison between HD patients and controls from 3 brain regions - cerebellum, frontal cortex [BA4, BA9] and caudate nucleus. Gene expression analysed using linear models from LIMMA package in Bioconductor suite. Experiment Overall Design: Large sample sizes were used...
ORGANISM(S): Homo sapiens 
2009-09-12 | E-GEOD-3790 | biostudies-arrayexpress
TranscriptomicsMethylomic profiling of human brain tissue supports a neurodevelopmental origin for schizophrenia.
Background: Schizophrenia is a severe neuropsychiatric disorder that is hypothesized to result from disturbances in early brain development, and there is mounting evidence to support a role for developmentally-regulated epigenetic variation in the molecular etiology of the disorder. Here, we describ...
ORGANISM(S): Homo sapiens 
2014-09-13 | E-GEOD-61380 | biostudies-arrayexpress
UnknownMapping mania symptoms based on focal brain damage.
Not available
S-EPMC7524493 | biostudies-literature
TranscriptomicsGene expression data from mouse HDAC4 KO pups, postnatal day 3
Reversible protein acetylation provides a central mechanism for controlling gene expression and cellular signaling events. It is governed by the antagonistic commitment of two enzymes families: the histone acetyltransferases (HATs) and the histone deacetylases (HDACs). HDAC4, like its class IIa coun...
ORGANISM(S): Mus musculus 
2014-07-30 | E-GEOD-49383 | biostudies-arrayexpress
UnknownPoloxamer-188 Exacerbates Brain Amyloidosis, Presynaptic Dystrophies, and Pathogenic Microglial Activation in 5XFAD Mice.
Not available
S-EPMC9533405 | biostudies-literature
UnknownA prospective longitudinal brain morphometry study of children with sickle cell disease.
Not available
S-EPMC6598682 | biostudies-literature
UnknownRepurposing Clemastine to Target Glioblastoma Cell Stemness.
Not available
S-EPMC10526458 | biostudies-literature
TranscriptomicsGene expression analysis in cortex of CRTC1 deficient mice and WT littermates
To identify gene expression changes associated with Crtc1 deficiency, we performed genome-wide transcriptome profile analyses by using mouse cDNA microarrays in the cortex of Crtc1‒/‒ and WT female mice BACKGROUND: Recent studies involve the arginine-decarboxylation product agmatine in mood regu...
ORGANISM(S): Mus musculus 
2016-07-18 | E-GEOD-80633 | biostudies-arrayexpress
TranscriptomicsA data-driven approach to preprocessing Illumina 450K methylation array data
Background: As the most stable and experimentally accessible epigenetic mark, DNA methylation is of great interest to the research community. The landscape of DNA methylation across tissues, through development and in disease pathogenesis is not yet well characterised. Thus there is a need for rapid...
ORGANISM(S): Homo sapiens 
2013-01-24 | E-GEOD-43414 | biostudies-arrayexpress
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