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MetabolomicsLipid Profiles of Human Brain Tumors Obtained by High-Resolution Negative Mode Ambient Mass Spectrometry

Alterations in cell metabolism, including changes in lipid composition occurring during malignancy, are well characterized for various tumor types. However, a significant part of studies that deal with brain tumors have been performed using cell cultures and animal models. Here, we present a data...

2021-11-18 | MTBLS1558 | MetaboLights
MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
MetabolomicsTargeted metabolomics of pancancer brain metastasis

The molecular heterogeneity of brain metastases hampers therapeutic development for cures. To address this unmet and urgent need, we constructed a comprehensive multi-omic, single cell, and spatially resolved atlas of 1,032 pan-cancer brain metastases, identifying four robust molecular subtypes ...

2025-12-22 | MTBLS13554 | MetaboLights
TranscriptomicsExpression data from human brain tumors and human normal brain
The characteristics of immune cells infiltrating pediatric brain tumors is largely unexplored. A better understanding of these characteristics will provide a foundation for development of immunotherapy for pediatric brain tumors. Gene expression profiles were used to identify immune marker gene that...
ORGANISM(S): Homo sapiens 
2013-08-25 | E-GEOD-50161 | biostudies-arrayexpress
TranscriptomicsTranscription profiling by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2910 | biostudies-arrayexpress
TranscriptomicsComparative genomic hybridization by array of human tumor cells with stem-like properties isolated from pediatric brain tumors
Background
Primitive brain tumors are the first cause of cancer-related death in children. Tumor cells with stem-like properties (TSCs), thought to account for tumorigenesis and therapeutic resistance, have been isolated from high-grade gliomas in adults. Whether TSCs are a common component of pe...
ORGANISM(S): Homo sapiens 
2011-09-07 | E-MEXP-2909 | biostudies-arrayexpress
TranscriptomicsArray-CGH in human glial brain tumors
Set of arrays organized by shared biological context, such as organism, tumors types, processes, etc. Characterization of DNA copy number changes in 54 glial brain tumors using a cDNA microarray-based comparative genomic hybridization method. Tumors: 54 fresh-frozen glioma specimens subjected to sta...
ORGANISM(S): Homo sapiens 
2010-06-10 | E-GEOD-1991 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue
Gene expression profiling of SEGA (subependymal giant cell astrocytoma) brain tumors as compared to control brain tissue.
ORGANISM(S): Homo sapiens 
2010-08-09 | E-MEXP-2351 | biostudies-arrayexpress
TranscriptomicsIdentification of differentially regulated splice variants and novel exons in glial brain tumors using exon arrays
Aberrant splice variants are involved in the initiation and/or progression of glial brain tumors. We therefore set out to identify splice variants that are differentially expressed between histological subgroups of gliomas. Splice variants were identified using a novel platform that profiles the exp...
ORGANISM(S): Homo sapiens 
2008-01-28 | E-GEOD-9385 | biostudies-arrayexpress
ProteomicsProteogenomic Discovery of Neoantigens Facilitates Personalized Multi-antigen Targeted T cell Immunotherapy for Brain Tumors
Neoantigen discovery in pediatric brain tumors is hampered by their low mutational burden and scant tissue availability. We developed a low-input proteogenomic approach combining tumor DNA/RNA sequencing and mass spectrometry proteomics to identify tumor-restricted (neoantigen) peptides arising from...
ORGANISM(S): Homo sapiens (Human) 
2021-11-02 | PXD029082 | Pride
Lc-msms Medulloblastoma Pediatric brain tumors 
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