Sort   by:  
 Page size 
MetabolomicsA microfluidic chip recapitulating the human neurovascular unit with a functional blood-brain barrier for modeling gut-brain interactions

The blood-brain barrier (BBB) is essential for central nervous system homeostasis, but most current in vitro models lack structural and functional fidelity. We developed a physiologically relevant human neurovascular unit microfluidic chip (hNVU-on-a-chip) incorporating brain microvascular endoth...

2025-10-28 | MTBLS13230 | MetaboLights
TranscriptomicsRNA-seq of mouse brain tissue repopulating microglia in response to traumatic brain injury
We assessed the roles of repopulating microglia in brain repair using mouse models. In this project, we show that removal of microglia from the mouse brain has little impact on the outcome of TBI but inducing the turnover of these cells through either pharmacologic or genetic approaches can yield a ...
ORGANISM(S): Mus musculus 
2020-02-15 | E-MTAB-8765 | biostudies-arrayexpress
ProteomicsAn Atlas of Proteome and Phosphoproteome Turnover Across Mouse Tissues and Brain Regions
Understanding how different mammalian tissues are regulated is central to biology. Since the same proteins often appear in multiple tissues, protein abundance, turnover, and post-translational modifications, like phosphorylation, are key factors that determine tissue-specific proteome properties. Ho...
ORGANISM(S): Mus musculus (Mouse) 
2025-03-11 | PXD055942 | Pride
Brain region Tmtpro Psilac Dia Phosphoproteome Mouse tissue Protein turnover Proteome 
ProteomicsMouse brain protein turnover - Brain protein turnover in mouse models of neurodegeneration, and in ageing healthy tissue
Brain protein turnover in mouse models of neurodegeneration, and in ageing healthy tissue
ORGANISM(S): Mus musculus (Mouse) 
2018-12-11 | PXD010671 | Pride
Silam brain proteome turnover 
ProteomicsLocal and global influences on protein turnover in neurons and glia.
Proteins exhibit dynamics in their expression level in response to intracellular and extracellular signals. Regulation of protein turnover allows cells to rapidly and efficiently remodel their proteomes. It is known that proteins can show very different turnover rates in different tissue of the same...
ORGANISM(S): Rattus norvegicus (Rat) 
2018-06-05 | PXD008596 | Pride
Proteome turnover Neurons Silac Glia 
GenomicsSpatial mapping of RNA turnover kinetics in the mouse brain
Spatial mapping of RNA turnover kinetics in the mouse brain
PRJNA1048974 | ENA
GenomicsSpatial mapping of RNA turnover kinetics in the mouse brain [scNT-seq2]
Spatial mapping of RNA turnover kinetics in the mouse brain [scNT-seq2]
PRJNA1048969 | ENA
GenomicsGenome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
We developed a system to study the DNA replication-independent turnover nucleosomes containing the histone variant H3.3 in mammalian cells. By measuring the genome-wide incorporation of H3.3 at different time points following epitope-tagged H3.3 expression, we find three categories of H3.3-nucleosom...
ORGANISM(S): Mus musculus 
2013-10-23 | E-GEOD-51505 | biostudies-arrayexpress
TranscriptomicsExpression data from amoeboid and ramified microglia isolated from the corpus callosum of 5-day and 4-week old rat brain
Microglia, the resident immune cells of the central nervous system (CNS), have two distinct phenotypes in the developing brain: amoeboid form, known to be amoeboid microglial cells (AMC) and ramified form, known to be ramified microglial cells (RMC) alongside several intermediate forms. The AMC are ...
ORGANISM(S): Rattus norvegicus 
2011-06-11 | E-GEOD-29885 | biostudies-arrayexpress
GenomicsSpatial mapping of RNA turnover kinetics in the mouse brain [Spatial NT-seq]
Spatial mapping of RNA turnover kinetics in the mouse brain [Spatial NT-seq]
PRJNA1048986 | ENA
Sort   by:  
 Page size