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ProteomicsMorquio A syndrome: identification of differential patterns of molecular pathway interactions in bone lesions
Mucopolysaccharidosis type IVA (MPS IVA; Morquio A syndrome) is a rare autosomal recessive lysosomal storage disease (LSD) caused by deficiency of a hydrolase enzyme, N-acetylgalactosamine-6-sulfate sulfatase, and characterized clinically by mainly musculoskeletal manifestations. The mechanisms unde...
ORGANISM(S): Mus musculus (Mouse) 
2024-05-24 | PXD042166 | Pride
Morquio a syndrome Rare disease Swath-ms Protein biomarker 
ProteomicsQuantitative Proteomic Study Unmasks Fibrinogen Pathway in Polycystic Liver Disease
(1) Background: Polycystic liver disease (PLD) is a heterogeneous group of congenital disorders characterized by bile duct dilatation and cyst development derived from cholangiocytes. Nevertheless, the cystogenesis mechanism is currently unknown and the PLD treatment is limited to liver transplantat...
ORGANISM(S): Mus musculus (Mouse) 
2022-04-04 | PXD031253 | Pride
Pld  swath  quantitative proteomics  therapeutic targets 
ProteomicsNovel phenotypical and biochemical findings in mucolipidosis type II
Mucolipidosis type II (ML II) is a rare lysosomal storage disorder caused by deficiency of the UDP-GlcNAc:N-acetylglucosamine-1-phosphotransferase enzyme, which catalyzes the synthesis of the mannose-6-phosphate (M6P) targeting signal for lysosomal acid hydrolases. This deficiency hinders lysosomal ...
ORGANISM(S): Homo sapiens (Human) 
2025-05-07 | PXD060270 | Pride
Mucolipidosis ii-iii  early findings  biochemistry  biomarkers  proteomic studies  lysosomal diseases. 
ProteomicsNeddylation of phosphoenolpyruvate carboxykinase 1 controls glucose metabolism
Neddylation is a post-translational mechanism that adds a ubiquitin-like protein, namely neural precursor cell expressed developmentally down-regulated protein 8, to target proteins, with yet-unknown consequences. Here we show in mice that neddylation in liver is modulated by nutrient availability. ...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-08 | PXD043054 | Pride
Pck1 Neddylation Glucose 
ProteomicsRed blood cells protein profile is modified in breast cancer patients
We characterized the proteomic composition of RBCs from 53 breast cancer patients (stages I-III and IV), compared with 33 healthy donors. For that, we performed two different proteomic analyses (LC-MS/MS in DDA mode-shotgun- and a SWATH-MS) using the Triple TOF 6600 technology.
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD030936 | Pride
Red blood cells (rbcs)  breast cancer Metastasis 
ProteomicsVenom Proteomics of Vespa velutina nigrithorax (Hym.: Vespidae) Queens and Workers: A Quantitative SWATH-MS Analysis
Health risks caused by stings from Vespa velutina nigrithorax (VV), also known as the yellow-legged Asian hornet, have become a public concern, but little is known about its venom composition. This study presents the proteome profile of the VV’s venom sac based on Sequential Window Acquisition of al...
ORGANISM(S): Vespa velutina nigrithorax 
2023-05-10 | PXD040764 | Pride
Asian hornet  vespa velutina nigrithorax  vespa spp.  proteomics  swath-ms  hymenopteran  venom  allergy. 
ProteomicsDetection of Circulating Serum Protein Biomarkers of Non-muscle Invasive Bladder Cancer after the Protein Corona-Silver Nanoparticles Analysis by SWATH-MS
Because cystoscopy is expensive and invasive, a new method of detecting non-invasive muscular bladder cancer (NMIBC) is needed. This study aims to identify potential serum protein markers for NMIBC to improve diagnosis and to found treatment approaches to avoid disease progression to a life-threaten...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD028310 | Pride
Protein corona (pc)  silver nanoparticles (agnps)  bladder cancer (bc)  bi-omarkers  fingerprinting  swath-ms 
ProteomicsProteomic analysis of extracellular vesicles derived from platelet concentrates treated with Mirasol® identifies biomarkers of platelet storage lesion
In blood banks, platelets are stored until 7 days after a pathogen reduction technology (PRT) treatment, Mirasol® (vitamin B2 plus UVB light) in the present case. The storage time under these conditions may have an impact on platelets and their releasate leading to potential adverse reactions follow...
ORGANISM(S): Homo sapiens (Human) 
2022-09-30 | PXD014694 | Pride
Extracellular vesicles  platelet concentrates  transfusion medicine  swath 
ProteomicsTreatment choice matters in multiple sclerosis: The role of extracellular vesicles in predicting treatment response.
Multiple sclerosis (MS) is an immune-mediated central nervous system disease whose course is unpredictable. Finding biomarkers that help to better comprehend thedisease’s pathogenesis iscrucial for supporting clinical decision-making. Blood extracellular vesicles (EVs) are membrane-bound particles s...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD038003 | Pride
Rheumatoid arthritis  subcortical stroke.icles Blood  exosomes  extracellular vesicles  multiple sclerosis  proteomic analysis Extracellular vesbiomarkers Intracerebral hemorrhage Rat Proteomics Blood 
ProteomicsLinking First-Pass Reperfusion Success to Proteomic Markers in Large and Medium Vessel Ischemic Stroke
Mechanical thrombectomy (MT) has improved disability outcomes after ischemic stroke (IS), mainly when the so-called modified first-pass effect (mFPE) is achieved. This study aims to explore the proteomic profiling of thrombi composition in those patients who achieved mFPE. A prospective study was co...
ORGANISM(S): Homo sapiens (Human) 
2026-03-30 | PXD066161 | Pride
Biological pathways  ischemic stroke  mechanical thrombectomy  proteomics  thromboinflammation 
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