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ProteomicsCTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD009541 | Pride
Brct dna damage lc-msms 
ProteomicsSir4 H-BRCT domain interacts with multiple phospho-proteins to regulate heterochromatic repression
In Saccharomyces cerevisiae, the Silent Information Regulator (SIR) proteins Sir2/3/4 form a complex suppressing transcription of genes at subtelomeric regions and the homothallic mating type (HM) loci. Here we identify a non-canonical BRCA1 C-terminal domain (H-BRCT) in Sir4 which is responsible fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-13 | PXD014119 | Pride
Tom1 Sir complex Heterochromatin Brct Dbf4 
GenomicsThe role of BRCT domain from LmjPES in Leishmania major biology
The role of BRCT domain from LmjPES in Leishmania major biology
PRJNA979236 | ENA
TranscriptomicsEffects of the expression of M1775R and A1789T BRCA1 missense variants on the transcriptome of HeLa cells
BRCA1 (breast cancer 1, early onset) mutations confer a high breast and ovarian cancer risk. Most of BRCA1 cancer-predisposing mutations originate truncated proteins, but missense mutations have also been detected in familial breast and ovarian cancer patients. These variants are rare and their role...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-MTAB-761 | biostudies-arrayexpress
GenomicsRNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
RNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
PRJNA674644 | ENA
TranscriptomicsThe role of BRCT domain from LmjPES in Leishmania major biology
To investigate the implications of LmjPES BRCT domain overexpression in Leishmania major. We generated a strain of L. major constitutively overexpressing LmjPES BRC domain and we compared its gene expression with other L. major strain no-overexpressing this domain.The data showed a role of LmjPES BR...
ORGANISM(S): Leishmania major 
2025-09-03 | GSE234048 | GEO
TranscriptomicsRNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
Given the prevalence of leishmaniasis and cancer, the co-existence of these two diseases may be merely coincidental. However, a number of epidemiological studies suggest that an association between these two entities does exist. Mammalian PES protein has been reported to be involved in different cel...
ORGANISM(S): Homo sapiens 
2022-11-16 | GSE160853 | GEO
UnknownStructural studies of the PARP-1 BRCT domain.
Not available
S-EPMC3195086 | biostudies-literature
UnknownCrystal structure and mutagenesis of a nucleic acid-binding BRCT domain in human PARP4.
Not available
S-EPMC12212138 | biostudies-literature
UnknownThe BRCT domain of PARP1 binds intact DNA and mediates intrastrand transfer.
Not available
S-EPMC8769213 | biostudies-literature
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