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ProteomicsCTDP1 BRCT domain PPI - CTDP1 regulates breast cancer survival and DNA repair through BRCT-specific interactions with FANCI
The BRCT domain is commonly found in DNA damage response proteins, but its role in the phosphatase CTDP1 is unknown. This project examined the protein-protein interactions (PPI) associated with the CTDP1 BRCT domain region only and identified 106 significant interacting partners. Many of these partn...
ORGANISM(S): Homo sapiens (Human) 
2019-06-04 | PXD009541 | Pride
Brct dna damage lc-msms 
ProteomicsSir4 H-BRCT domain interacts with multiple phospho-proteins to regulate heterochromatic repression
In Saccharomyces cerevisiae, the Silent Information Regulator (SIR) proteins Sir2/3/4 form a complex suppressing transcription of genes at subtelomeric regions and the homothallic mating type (HM) loci. Here we identify a non-canonical BRCA1 C-terminal domain (H-BRCT) in Sir4 which is responsible fo...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2019-09-13 | PXD014119 | Pride
Tom1 Sir complex Heterochromatin Brct Dbf4 
TranscriptomicsExogenous BRCT-GST of PARP1 bind to wild-type p53. p53 was overxpressed after UV treatment in U2OS.
Exogenous BRCT-GST in U2OS bind to wild-type p53 in a phosphorylation-dependent manner, after UV treatment. BRCT-GST fusion protected cells from apoptotic cell death.
ORGANISM(S): Homo sapiens 
2022-12-30 | E-MTAB-3619 | biostudies-arrayexpress
TranscriptomicsExogenous BRCT-GST of PARP1 bind to wild-type p53. p53 was overexpressed after UV treatment in U2OS.
Exogenous BRCT-GST in U2OS bind to wild-type p53 in a phosphorylation-dependent manner, after UV treatment. BRCT-GST fusion protected cells from apoptotic cell death and impact of miRNAs responsive to p53 activation.
ORGANISM(S): Homo sapiens 
2024-03-02 | E-MTAB-3628 | biostudies-arrayexpress
GenomicsThe role of BRCT domain from LmjPES in Leishmania major biology
The role of BRCT domain from LmjPES in Leishmania major biology
PRJNA979236 | ENA
TranscriptomicsEffects of the expression of M1775R and A1789T BRCA1 missense variants on the transcriptome of HeLa cells
BRCA1 (breast cancer 1, early onset) mutations confer a high breast and ovarian cancer risk. Most of BRCA1 cancer-predisposing mutations originate truncated proteins, but missense mutations have also been detected in familial breast and ovarian cancer patients. These variants are rare and their role...
ORGANISM(S): Homo sapiens 
2012-06-01 | E-MTAB-761 | biostudies-arrayexpress
UnknownStructure of the 53BP1 BRCT region bound to p53 and its comparison to the Brca1 BRCT structure.
Not available
S-EPMC155350 | biostudies-literature
GenomicsRNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
RNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
PRJNA674644 | ENA
TranscriptomicsRNA sequencing analysis of HEK293T cells infected with a lentivirus coding the BRCT domain from Leishmania major Pes protein
Given the prevalence of leishmaniasis and cancer, the co-existence of these two diseases may be merely coincidental. However, a number of epidemiological studies suggest that an association between these two entities does exist. Mammalian PES protein has been reported to be involved in different cel...
ORGANISM(S): Homo sapiens 
2022-11-16 | GSE160853 | GEO
UnknownTandem BRCT Domains: DNA's Praetorian Guard.
Not available
S-EPMC3082952 | biostudies-literature
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