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ProteomicsBreak-induced replication is enhanced by a phospho-activated RPA-binding module in Pol32
Break-induced replication (BIR) mediates single-ended DNA double-strand break (DSB) repair. Upon strand invasion into a homologous repair template, BIR is catalysed by a minimal replisome comprising PCNA, DNA polymerase delta, and the Pif1 helicase. Here, we identify an interaction between Polymeras...
ORGANISM(S): Escherichia coli Saccharomyces cerevisiae (Baker's yeast) 
2026-06-15 | PXD074712 | Pride
Cdc5 Break-induced replication Vanquish neo uhplc Ddk Orbitrap exploris 480 Pol32 Cka2 Saccharomyces cerevisiae 
ProteomicsTRF1 averts chromatin remodelling, recombination and replication dependent-Break Induced Replication at mouse telomeres
Telomeric repeat sequences are prone to induce replication stress and one of the core telomere binding proteins, TRF1, is thought to counteract these problems. The molecular mechanisms coming into play upon TRF1 loss were not clearly defined though. This study combines an inducible TRF1 loss with te...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-22 | PXD017022 | Pride
Embryonic fibroblasts Lc-msms Teleomere Mus musculus Shelterin complex 
ProteomicsProteome-wide analysis of SUMO2 targets in response to pathological DNA replication stress in human cells
SUMOylation is a form of post-translational modification involving covalent attachment of SUMO (Small Ubiquitin-like Modifier) polypeptides to specific lysine residues in the target protein. In human cells, there are four SUMO proteins, SUMO1–4, with SUMO2 and SUMO3 forming a closely related subfami...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-28 | MSV000080699 | MassIVE
GenomicsDNA polymerase Δ synthesizes both strands during break-induced replication
DNA polymerase Δ synthesizes both strands during break-induced replication
PRJNA551884 | ENA
TranscriptomicsPost-replicative formation of cohesion is required for repair and induced by a single DNA break
Sister chromatid cohesion, established during replication by the protein complex Cohesin, is essential for both chromosome segregation and double-strand break (DSB) repair. Normally cohesion formation is strictly limited to the S-phase of the cell cycle, but DSBs can trigger cohesion also after DNA ...
ORGANISM(S): Saccharomyces cerevisiae 
2010-06-10 | E-GEOD-8270 | biostudies-arrayexpress
ProteomicsATR inhibition rewires cellular signaling networks in response to pathologic replication stress
DNA replication stress is the major cause of genomic instability in human cells. The ataxia telangiectasia and Rad3-related kinase (ATR) plays an essential role in the cellular response to replication stress and inhibition of ATR has emerged as therapeutic strategy for the treatment of cancer. Howev...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080795 | MassIVE
UnknownTRF1 averts chromatin remodelling, recombination and replication dependent-break induced replication at mouse telomeres.
Not available
S-EPMC6986873 | biostudies-literature
OtherDNA polymerase Δ synthesizes both strands during break-induced replication
We applied our ribonucleotide mapping technique HydEn-seq to study DNA polymerase usage during break-induced replication (BIR) in the budding yeast Saccharomyces cerevisiae.
ORGANISM(S): Saccharomyces cerevisiae 
2019-07-01 | GSE133558 | GEO
UnknownBreak-induced replication promotes fragile telomere formation.
Not available
S-EPMC7528700 | biostudies-literature
UnknownBreak-induced replication occurs by conservative DNA synthesis.
Not available
S-EPMC3746906 | biostudies-literature
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