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TranscriptomicsEvaluation of gene expression profile in postmortem brain with Alzheimer´s disease-type neuropathological changes
Unravel the mechanisms underlying brain aging and Alzheimer´s disease (AD) has been difficult because of complexity of the networks that drive these aging-related changes. Analysis of the gene expression in the brain is a valuable tool to study the function of the brain under normal and pathological...
ORGANISM(S): Homo sapiens 
2013-01-11 | E-GEOD-13214 | biostudies-arrayexpress
TranscriptomicsNo-match ORESTES explored as tumor markers
Sequencing technologies together with new bioinformatics tools have led to the complete sequencing of various genomes. However, information regarding the human transcriptome and its annotation is yet to be completed. The Human Cancer Genome Project, using ORESTES (open reading frame EST sequences) m...
ORGANISM(S): Homo sapiens 
2009-04-13 | E-GEOD-12737 | biostudies-arrayexpress
TranscriptomicsDuctal Carcinoma Progression
To obtain insight into the molecular basis of ductal carcinoma in situ (DCIS) and its progression by infiltrating surrounding tissue, we have performed cellular-based gene expression analysis of pure DCIS and DCIS with co-existing invasive ductal carcinoma (IDC) and compared the histological and mol...
ORGANISM(S): Homo sapiens 
2008-04-04 | E-GEOD-11042 | biostudies-arrayexpress
TranscriptomicsHPV16 E7 expression effect on expression profile mediated by tumor necrosis factor
Acute expression of E7 oncogene from HPV-16 or HPV-18 is sufficient to overcome tumor necrosis factor-alfa (TNF) cytostatic effect on primary human keratinocytes. In the present study we investigated the molecular basis of E7-induced TNF resistance through a comparative analysis of the effect of thi...
ORGANISM(S): Homo sapiens 
2010-06-24 | E-GEOD-17892 | biostudies-arrayexpress
TranscriptomicsBiology of human melanoma
In normal skin, interactions between melanocytes and keratinocytes, and between melanocytes and the basal membrane are functionally relevant for maintenance of homeostasis and epidermal melanin unit whose deregulation may trigger a continuous proliferation of the melanocytes. In order to further elu...
ORGANISM(S): Homo sapiens 
2011-10-31 | E-GEOD-17275 | biostudies-arrayexpress
TranscriptomicsGene expression study in choroid plexus
The choroid plexus (CP) constitutes one of the blood–brain barriers – the blood cerebrospinal fluid barrier. It is formed by a monolayer of epithelial cells located within the brain ventricles and in addition to be responsible for the formation of the cerebrospinal fluid (CSF) is ideally positioned ...
ORGANISM(S): Mus musculus 
2010-08-19 | E-GEOD-23714 | biostudies-arrayexpress
TranscriptomicsAIRE hypoexpression and transcriptome profiles correlate with thymic impairment in Down syndrome
Down syndrome (DS) patients frequently develop organ-specific autoimmune disorders, particularly endocrinopathies and coeliac disease, as well as an increased susceptibility to mucosal candidiasis. These clinical features resemble APECED (autoimmune-polyendocrinopathy-candidiasis-ectodermal-dystroph...
ORGANISM(S): Homo sapiens 
2011-11-28 | E-GEOD-23910 | biostudies-arrayexpress
TranscriptomicsGene expression profile of classical Hodgkin lymphoma according to Epstein-Barr infection status
Transcriptional profiling of Human Hodkin Lymphoma lineages infected or not by Epstein Baar Virus (EBV). We compared EBV infected lineage L591 and not EBV infected lineages L428, L1236 and KMH2. Goal was to determine presence versus absence of EBV infection on global gene expression of Hodkin Lymp...
ORGANISM(S): Homo sapiens 
2011-12-31 | E-GEOD-21586 | biostudies-arrayexpress
TranscriptomicsTransduction signaling signature of Wilms tumor revealed by parallel analysis of kidney differentiation
Precise regulation of transduction signaling pathways genes is crucial for correct differentiation of kidney cells and perturbation may lead to tumor onset. Wilms tumors (WT), or nephroblastoma, originates from the metanephric blastema cells, which were unable to complete the differentiation, result...
ORGANISM(S): Mus musculus 
2011-12-07 | E-GEOD-25965 | biostudies-arrayexpress
TranscriptomicsCo-expression network analysis from genes involved with neural-differentiation shows specific pattern in patients with schizophrenia
Schizophrenia is a severe and debilitating neuropsychiatric disorder with the involvement of genetic and environmental factors contributing to its pathogenesis. The specific role of the brain cell types in the disease remains uncovered due to the difficulties in accessing diseased tissue. This study...
ORGANISM(S): Homo sapiens 
2014-10-09 | E-GEOD-62105 | biostudies-arrayexpress
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