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ProteomicsEpistasis studies reveal redundancy among calcium-dependent protein kinases in motility and invasion of malaria parasites
In malaria parasites, evolution of parasitism has been linked to functional optimisation. Despite this optimisation, most members of a calcium-dependent protein kinase (CDPK) family show genetic redundancy during erythrocytic proliferation. To identify relationships between phospho-signalling pathwa...
ORGANISM(S): Plasmodium berghei ANKA 
2018-09-17 | PXD011096 | Pride
Plasmodium berghei Schizont Cdpk 
ProteomicsPhosphatidic acid governs natural egress in Toxoplasma gondii via a guanylate cyclase receptor platform
Toxoplasma gondii is able to establish a life-long chronic infection in human and animals. Host cell entry and egress from infected cells are two key steps in the lytic cycle of this obligate intracellular parasite that ensures its survival and dissemination. Egress is a temporally orchestrated proc...
ORGANISM(S): Toxoplasma gondii 
2018-11-14 | PXD011692 | Pride
Toxoplasma dondii  guanylyl cyclase 
ProteomicsA divergent cyclin/cyclin-dependent kinase complex controls progression through the atypical replicative cycles during Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria-causing parasites have evolved unique cell-cycles with a repertoire of ancestral CDKs and cyclins whose functions and interdependency remain elusive. Here, we sho...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-25 | PXD017308 | Pride
Soc2 Co-ip Crk5 Plasmodium berghei 
ProteomicsDiscovery of kinetochore and spindle assembly checkpoint proteins in apicomplexan parasites
Kinetochores are multiprotein assemblies that bind chromosomes to the spindle during mitosis. Despite conserved roles, repertoires of kinetochore proteins vary greatly across eukaryotes. In particular, most known components are not clearly detected in a group of parasites known as the Apicomplexa. F...
ORGANISM(S): Plasmodium berghei ANKA 
2023-03-11 | PXD028595 | Pride
Spindle assembly Lc-msms Apicomplexan parasite Immunoprecipitation 
ProteomicsThe Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and zoites in Plasmodium berghei
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, l...
ORGANISM(S): Plasmodium berghei ANKA 
2023-02-17 | PXD035557 | Pride
Lc-msms Plasmodium berghei Malarai Dia Ubiquitome 
ProteomicsThe Skp1-Cullin1-FBXO1 complex is a pleiotropic regulator required for the formation of gametes and zoites in Plasmodium berghei
Malaria-causing parasites of the Plasmodium genus undergo multiple developmental phases in the human and the mosquito hosts regulated by various post-translational modifications. While ubiquitination by multi-component E3 ligases is key to regulate a wide range of cellular processes in eukaryotes, l...
ORGANISM(S): Plasmodium berghei ANKA 
2023-02-17 | PXD035526 | Pride
Lc-msms Plasmodium berghei Malaria Immunoprecipitation 
ProteomicsA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogonyA unique and divergent cyclin/cyclin-dependent kinase complex controls DNA replication during atypical cell-cycles of Plasmodium berghei gametogony
Cell-cycle transitions are generally triggered by variations in the activity of cyclin-dependent kinases (CDKs) bound to cyclins. Malaria parasites express ancestral CDKs and cyclins, whose functions and interdependency remain elusive. Here, we show that the unique Plasmodium berghei CDK-related kin...
ORGANISM(S): Plasmodium berghei ANKA 
2020-02-18 | PXD017283 | Pride
Lc-msms Plasmodium berhei Tmt10 Phosphorylation Cyclin-dependent kinase 
ProteomicsUGO is a multipass membrane protein that is key to sense and transduce cues for schizont egress and gametocyte activation in malaria parasites
Many critical events in the Plasmodium lifecycle depend on tight regulation of cGMP homeostasis by guanylyl cyclases (GC) and phosphodiesterases including egress of schizonts from the host erythrocyte and activation of gametocytes upon a mosquito blood-feed. Both processes are triggered by distinct ...
ORGANISM(S): Plasmodium berghei ANKA 
2023-04-28 | PXD035569 | Pride
Lc-msms Gametocyte Immunoprecipitation Plasmodium berghei 
ProteomicsA Protein Kinase G -interacting protein regulates critical calcium signals in malaria parasites (Co-IP)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG) . One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito . However, how PKG c...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020210 | Pride
Gametocytes Lc-msms Plasmodium Co-ip 
ProteomicsA Protein Kinase G-interacting protein regulates critical calcium signals in malaria parasites (phosphoproteomic)
In malaria parasites, cGMP signalling is mediated by a single cGMP-dependent protein kinase (PKG). One of the major functions of PKG is to control calcium signals essential for the parasite to exit red blood cells or for the transmission of the gametocyte stages to the mosquito. However, how PKG con...
ORGANISM(S): Plasmodium berghei ANKA 
2021-01-25 | PXD020189 | Pride
Gametocytes Lc-msms Plasmodium Phosphoproteomic 
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