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TranscriptomicsIntegrated transcriptomic and proteomic analyses of P. falciparum gametocytes: molecular insight into sex-specific processes and translational repression
Sexual differentiation of malaria parasites into gametocytes in the vertebrate host and subsequent gamete fertilisation in mosquitoes is essential for the spreading of the disease. The molecular processes orchestrating these transitions are far from fully understood. Here we report the first transcr...
ORGANISM(S): Plasmodium falciparum 
2016-06-28 | E-GEOD-75795 | biostudies-arrayexpress
TranscriptomicsGlobal expression profiling reveals shared and distinct transcript signatures in arrested act2(-) and CDPK4(-) Plasmodium berghei gametocytes
Gametocytogenesis and gametogenesis in malaria parasites are complex processes of cell differentiation and development likely involving many gene products. Gametocytes develop in the blood of the vertebrate host but mature gametocytes are not activated until taken up by the mosquito vector. Several ...
ORGANISM(S): Plasmodium berghei 
2015-09-15 | E-GEOD-65032 | biostudies-arrayexpress
TranscriptomicsPlasmodium falciparum W2/Dd2 Day 8 gametocytes
The sexual stages are vital phases in malaria parasite transmission and are the targets of various interventions such as transmission blocking vaccines. The molecular mechanisms underlying sexual development, however, remain poorly understood. We report mappping of a determinant previously linked to...
ORGANISM(S): Plasmodium falciparum 
2010-06-10 | E-GEOD-2265 | biostudies-arrayexpress
TranscriptomicsIdentification of a subtelomeric gene family expressed during the asexual-sexual stage transition in Plasmodium falciparum
For malaria transmission, the parasite must undergo sexual differentiation into mature gametocytes. However, the molecular basis for this critical transition in the parasites life cycle is unknown. Six previously uncharacterized genes, Pfg14.744, Pfg14.745, Pfg14.748, Pfg14.763, Pfg14.752 and Pfg6.6...
ORGANISM(S): Plasmodium falciparum 
2014-10-16 | E-GEOD-62364 | biostudies-arrayexpress
ProteomicsDeciphering Membrane Protein Complexes in Plasmodium falciparum Gametocytes via Cross-Linking Mass Spectrometry and Structural Modeling
Malaria is a disease targeting the most vulnerable people. It is caused by the parasite Plasmodium falciparum, and is transmitted to humans by Anopheles mosquitos during a blood meal, who are in turn infected by the parasite if they feed on an infected human. While current eradication efforts focus ...
ORGANISM(S): Plasmodium falciparum 58.1 Homo sapiens (Human) 
2026-04-09 | PXD067699 | Pride
Gametocytes Malaria Cross-linking Plasmodium Alphafold 
ProteomicsPlasmodium yoelii zygotes and female gametocytes
Plasmodium yoelii zygotes or female gametocytes were purified by FACS and analyzed by DIA LC-MS.
ORGANISM(S): Plasmodium Yoelii (ncbitaxon:5861) 
2023-06-13 | MSV000092154 | MassIVE
ProteomicsP falciparum Pf377 protein complex in gametocytes
The identification of Pf377 interacting proteins in the osmiophilic bodies in P. falciparum gametocytes. In a comparative proteomics approach, immunopurified Pfg377 complexes were obtained in wild type and Osmiophilic Body -depleted gametocytes (Pf377 knock out gametocytes) and were analyzed by LC-M...
ORGANISM(S): Plasmodium falciparum (isolate 3D7) 
2018-10-26 | PXD004088 | Pride
Gametocyte Malaria Pf377 Osmiophilic body P. falciparum 
TranscriptomicsPlasmodium berghei transcriptome for female gametocytes, male gametocytes, and asexual erythrocytic stages
Plasmodium berghei transcriptome for female gametocytes, male gametocytes, and asexual erythrocytic stages
ORGANISM(S): Plasmodium berghei ANKA 
2017-08-21 | GSE102167 | GEO
MetabolomicsAnalysis of sex-specific lipid metabolism of Plasmodium falciparum points to the importance of sphingomyelin for gametocytogenesis
Male and female Plasmodium falciparum gametocytes are the parasite lifecycle stage responsible for transmission of malaria from the human host to the mosquito vector. Not only are gametocytes able to survive in radically different host environments, but they are also precursors for male and female g...
2022-04-05 | MTBLS4137 | MetaboLights
ProteomicsProteomic analyses identified distinct types of vesicles essential for egress of Plasmodium falciparum gametocytes from red blood cells
Transmission of malaria parasites to the mosquito is mediated by sexual precursor cells, the gametocytes. Upon entering the mosquito midgut, the gametocytes egress from the enveloping erythrocyte while passing through gametogenesis. Egress follows an inside-out mode during which the membrane of the ...
ORGANISM(S): Plasmodium Falciparum 
2024-01-25 | PXD039679 | JPOST Repository
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