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TranscriptomicsA new approach for the study of lung smooth muscle phenotypes and its application in asthma
We developed a new method for the isolation of bronchial smooth muscle cells. This method is built upon a double fluorescent mouse SMA-GFP;NG2-DsRed and cell sorting. Using this method, we isolated bronchial smooth muscle cells from control and asthmatic C57BL/6J mice for gene profiling. Double fluo...
ORGANISM(S): Mus musculus 
2014-03-13 | E-GEOD-45723 | biostudies-arrayexpress
TranscriptomicsSphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells
Background: Increased proliferation of airway smooth muscle (ASM) cells leading to hyperplasia and increased ASM mass is one of the most characteristic features of airway remodelling in asthma. A bioactive lipid, sphingosine-1-phosphate (S1P), has been suggested to affect airway remodelling by stimu...
ORGANISM(S): Homo sapiens 
2015-06-18 | E-GEOD-58657 | biostudies-arrayexpress
TranscriptomicsLarge-scale profiling of intracellular signalling pathway activation reveals major distinctions between airway smooth muscle cells of asthmatics and non-asthmatics.
Signalling pathways regulate all major cellular events in health and disease, including asthma development and progression. Complexity of human intracellular signalization can be explored using novel systemic approaches that exploit whole-transcriptome analysis. Cap-analysis-of-gene-expression (CAGE...
ORGANISM(S): Homo sapiens 
2016-02-17 | E-GEOD-63744 | biostudies-arrayexpress
ProteomicsSevere asthmatic bronchial smooth muscle decreases epithelial response to rhinovirus infection.
Asthma is a very frequent airway disease that affects 6 to 20% of the population. Severe asthma, represents 3 to 5% of all asthmatic patients and is histologically characterized by an increased bronchial smooth muscle (BSM) mass and clinically by viral exacerbations. Functionally, BSM remodeling had...
ORGANISM(S): Homo sapiens (Human) 
2023-05-02 | PXD015604 | Pride
Epithelium Smooth muscle cells Asthma 
ProteomicsAnalysis of proteins in supernatant and precipitate fractions of human bronchial smooth muscle cells by 1D SDS-PAGE and quantitative LC-MS/MS
Supernatant and precipitate protein fractions of human bronchial smooth muscle cells (HBSMC) after sonication and centrifugation were analyzed using 1D SDS-PAGE. The gel lanes were cube-cut into thirty-three 1.1 mm x 1.1 mm x 1 mm (gel thickness) squares and each gel piece was subjected to in-gel d...
ORGANISM(S): Homo sapiens (Human) 
2019-01-03 | PXD010036 | Pride
Precipitation fraction 1d sds-page Supernatant fraction Bronchial smooth muscle cells Quantitative lc-ms/ms 
TranscriptomicsTranscriptional Profiling of cultured human airway smooth cells from subjects with and without asthma
To identify transcriptional differences / intrinsic abnormalities of human airway smooth muscle cells from patients with and without asthma.
ORGANISM(S): Homo sapiens 
2018-10-27 | E-MTAB-7346 | biostudies-arrayexpress
ProteomicsProteomic analysis of bronchial epithelium challenged with bronchial smooth muscle extracellular vesicles
The main objective of CHARMACOMA is to explore the capacity of the severe asthmatic bronchial smooth muscle to modify bronchial epithelium physiology from a metabolic point of view.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD055949 | Pride
Bronchial epithelium 
ProteomicsProteomic analysis of bronchial epithelium challenged with bronchial smooth muscle extracellular vesicles
The main objective of CHARMACOMA is to explore the capacity of the severe asthmatic bronchial smooth muscle to modify bronchial epithelium physiology from a metabolic point of view.
ORGANISM(S): Homo sapiens (Human) 
2026-02-09 | PXD059603 | Pride
Bronchial epithelium 
TranscriptomicsSmooth Muscle Cells
This set contains 68 arrays of two series of experiments. 60 arrays are used to profile the heterogeneity of SMCs from different anatomic locations. 8 arrays are used to profile the change of gene expression of vascular smooth muscle cells upon serum exposure. An all pairs experiment design type is ...
ORGANISM(S): Homo sapiens 
2007-09-27 | E-GEOD-7195 | biostudies-arrayexpress
TranscriptomicsHuman Airway Smooth Muscle Transcriptome Changes in Response to Asthma Medications
Rationale: Asthma is a chronic inflammatory airway disease. The most common medications used for its treatment are β2-agonists and glucocorticosteroids, and one of the primary tissues that these drugs target in the treatment of asthma is the airway smooth muscle. We used RNA-Seq to characterize the ...
ORGANISM(S): Homo sapiens 
2014-01-01 | E-GEOD-52778 | biostudies-arrayexpress
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