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TranscriptomicsNext generation sequencing analysis of microRNAs in brown preadipocytes and in vitro differentiated mature brown fat cells
We performed a genome-wide deep sequencing analysis of the microRNAs abundant in mesenchymal stem cells (MSCs) derived from murine brown adipose tissue and in in vitro differentiated mature brown adipocytes. Several microRNAs were identified as differentially regulated when comparing datasets from M...
ORGANISM(S): Mus musculus 
2013-05-28 | E-GEOD-45499 | biostudies-arrayexpress
TranscriptomicsA methyltransferase EHMT1 controls brown adipose cell fate and adaptive thermogenesis through a PRDM16 complex
Brown adipose tissue (BAT) dissipates chemical energy in the form of heat, as a defense against hypothermia and obesity. Current evidence indicates that brown adipocytes arise from Myf5+-dermotomal precursors through the action of a PRDM16-C/EBP-_ transcriptional complex; however, the underlying mec...
ORGANISM(S): Mus musculus 
2013-11-07 | E-MTAB-1704 | biostudies-arrayexpress
TranscriptomicsRNA-seq comparison of primary mouse classical brown, beige, and white adipocytes
Classical brown adipocytes in interscapular BAT (Myf-5 derived) and inducible beige cells in WAT (non-Myf-5 derived) have distinct developmental origins, although both cell types have morphological and biochemical characteristics of brown fat such as the expression of UCP1. This raises an important ...
ORGANISM(S): Mus musculus 
2015-03-16 | E-MTAB-2624 | biostudies-arrayexpress
TranscriptomicsBiological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver
This SuperSeries is composed of the following subset Series: GSE25323: Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal White Adipose Tissue, and Liver (Nov 2009 dataset) GSE25324: Biological Aging and Circadian Mechanisms in Murine Brown Adipose Tissue, Inguinal Wh...
ORGANISM(S): Mus musculus 
2012-03-15 | E-GEOD-25325 | biostudies-arrayexpress
TranscriptomicsExpression data from the seed coats of black (iRT) and brown (irT) soybean variant for alleles of the R locus
The seed coat of black (iRT) soybean with the dominant R allele begins to accumulate cyanic pigments at the transition stage of seed development (300 – 400 mg fresh seed weight), whereas the brown (irT) nearly-isogenic seed coat with the recessive r allele lacks cyanic pigments at all stages of seed...
ORGANISM(S): Glycine max 
2011-08-22 | E-GEOD-26208 | biostudies-arrayexpress
TranscriptomicsExpression Data from Bone Marrow Progenitor-Derived Adipocytes, White Adipocytes and Brown Adipocytes.
We have identified a population of adipocytes in fat tissue that arise from bone marrow-derived progenitor cells. We used microarrays to compare the global gene expression patterns of the bone marrow progenitor-derived adipocytes as well as conventional white and brown adipocytes to evaluate the rel...
ORGANISM(S): Mus musculus 
2010-01-08 | E-GEOD-19757 | biostudies-arrayexpress
TranscriptomicsImproved transcription and translation with L-leucine stimulation of mTORC1
Roberts syndrome (RBS) is a human developmental disorder caused by mutations in the cohesin acetyltransferase ESCO2. We previously reported that mTORC1 was inhibited and overall translation was reduced in RBS cells. Treatment of RBS cells with L-leucine partially rescued mTOR function and protein sy...
ORGANISM(S): Homo sapiens 
2016-01-15 | E-GEOD-64962 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of rat folliculogenesis reveals glial derived neurotrophic factor promotes ovarian primordial follicle development
Female fertility is determined in part by the size and development of the primordial follicle pool. The current study investigates the role of glial cell-line derived neurotrophic factor (GDNF) in the regulation of primordial follicle development in the ovary. Ovaries from four-day old female rat pu...
ORGANISM(S): Rattus norvegicus 
2008-06-11 | E-GEOD-11133 | biostudies-arrayexpress
TranscriptomicsTranscript profiles of juvenile female brown trout exposed to glyphosate and Roundup herbicides.
This study aimed to investigate the hepatic transcriptional response of brown trout to glyphosate, and its formulated product, Roundup. We exposed juvenile female brown trout to three concentrations of glyphosate (0.01, 0.5 and 10 mg/L) and Roundup (0.01, 0.5 and 10 mg/L glyphosate acid equivalent) ...
ORGANISM(S): Salmo trutta 
2015-04-16 | E-GEOD-56855 | biostudies-arrayexpress
TranscriptomicsHepatic transcriptional signatures of exposure to oestradiol (E2) and the herbicide linuron in mature male brown trout
These studies aimed to investigate the hepatic transcriptional response of brown trout to the natural estrogen, E2, and the herbicide linuron. We exposed mature male brown trout to three concentrations of each chemical for 4 days and sequenced the hepatic transcriptome of 3 individuals per treatment...
ORGANISM(S): Salmo trutta 
2015-05-08 | E-GEOD-57490 | biostudies-arrayexpress
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