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GenomicsCistromic and epigenomic changes in Prdm16 knock-out brown adipose tissue
Prdm16 is a transcription factor that drives a complete program of brown adipocyte differentiation, but the mechanism by which Prdm16 activates gene transcription remains unknown. Utilizing ChIP-seq teqhnique, we found that Prdm16 binds to chromatin at/near many brown fat-selective genes in BAT. Int...
ORGANISM(S): Mus musculus 
2015-02-10 | E-GEOD-63965 | biostudies-arrayexpress
ModelsMODEL1703310000_url.xml
Ramirez2017 - Human global metabolism in brown and white adipocytes Recon 2.1A, an update to Recon 2.1x, is suitable for quantitatively-realistic results for flux balance analysis in human metabolism. This model is described in the article: Integrating Extracellular Flux Measur...
MODEL1703310000 | BioModels
ProteomicsItaconate stabilizes CPT1a to enhance lipid utilization during inflammation
One primary metabolic manifestation of inflammation is the diversion of cis-aconitate within the tricarboxylic acid (TCA) cycle to synthesize the immunometabolite itaconate. Itaconate is well established to possess immunomodulatory and metabolic effects within myeloid cells and lymphocytes, however,...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-29 | PXD047706 | Pride
Thermogenesis Itaconate Liver Sepsis Fatty acid metabolism 
GenomicsUQ Diamantina Institute
Data Access Committee EGAC01000000021
EGAC01000000021 | EGA
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
BAT transcriptome from control and brown adipocyte-specific Rev-erbα/β double knockout mice housed at thermoneutrality or cold-challenged for 6 hours. Brown adipose tissue (BAT) samples were collected from control and brown adipocyte-specific Rev-erbα/β double knockout mice (Ucp1-Cre; Nr1d1/2 fl/fl)...
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17580 | biostudies-arrayexpress
TranscriptomicsMitochondrial carrier SLC25A34 links clock, diet, and temperature control of adipocyte lipid cycling
Transcriptome from immortalized murine brown adipocytes BMC. Cells were transfected with siRNA construct #1 or construct #2 (pool) or non-targeting control on day 3 of differentiation and harvested on day 7 of differentiation.
ORGANISM(S): Mus musculus 
2026-09-23 | E-MTAB-17577 | biostudies-arrayexpress
ProteomicsImpact of glycan positioning on HIV-1 Env glycan shield density, function, and antibody recognition
N-glycans, which represent >50% mass of the HIV-1 envelope (Env) trimer, play important roles for virus-cell entry and immune evasion. How each glycan unit interacts to shape the Env protein-sugar complex and affects Env function is not well understood. Here, high-resolution glycomics analysis of ...
ORGANISM(S): HIV-1 M:G_PT919 
2021-09-09 | PXD017941 | Pride
Glycosylation Env Hiv N262 Gp120 
TranscriptomicsVallier 3day endoderm
Transcriptional profiling of H9 human embryonic stem cells differentiated towards early endoderm over 72 hours in chemically defined media.
ORGANISM(S): Homo sapiens 
2011-01-26 | E-MTAB-467 | biostudies-arrayexpress
UnknownSLCO2B1 and SLCO1B3 may determine time to progression for patients receiving androgen deprivation therapy for prostate cancer.
Not available
S-EPMC3138634 | biostudies-literature
GenomicsVariants from a subset of genes from WES of adult AML patient samples
The aim if this study was to identify variants in a specific list of genes in samples from adult AML patients. The gene list includes DNA repair and mitochondrial respiratory chain genes.
EGAS00001006185 | EGA
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