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TranscriptomicsGene expression from mouse white, brown, and perivascular adipose tissue
Thoracic perivascular adipose tissue (PVAT) is a unique adipose depot that likely influences vascular function and susceptibility to pathogenesis in obesity and metabolic syndrome. Surprisingly, PVAT has been reported to share characteristics of both brown and white adipose, but a detailed direct co...
ORGANISM(S): Mus musculus 
2011-08-22 | E-GEOD-28440 | biostudies-arrayexpress
TranscriptomicsBlood gene expression of rats exposed to acetaminophen or methyl parathion
The purpose of this study was to investigate whether expression of specific genes in peripheral blood can be used as surrogate marker(s) to detect and distinguish target organ-specific chemical toxicity in rats. Rats were intraperitoneally administered a single, acute dose of a well-established hep...
ORGANISM(S): Rattus norvegicus 
2010-04-08 | E-GEOD-13442 | biostudies-arrayexpress
TranscriptomicsCHD5, A Brain-Specific Chromatin Remodeling Enzyme, Regulates Expression Of Neuronal Genes.
CHD5 is frequently deleted in neuroblastoma, and appears to be a tumor suppressor gene; however, little is known about the role of CHD5. We found CHD5 mRNA was restricted to brain; by contrast most other remodeling ATPases were broadly expressed. CHD5 protein isolated from mouse brain was associat...
ORGANISM(S): Rattus norvegicus 
2011-09-21 | E-GEOD-27620 | biostudies-arrayexpress
GenomicsCHD7 targets active gene enhancer elements to modulate ES cell-specific gene expression.
Gene expression changes were measured between mouse ES cells of three genotypes: WT Chd7, Heterzygous Chd7 Null, Homozygous Chd7 Null. The hypothesis being tested was that CHD7, a chromatin remodeling protein, functions as a transcriptional regulator. This experiment was performed to detect gene t...
ORGANISM(S): Mus musculus 
2010-06-15 | E-GEOD-22341 | biostudies-arrayexpress
UnknownSafety and efficacy of the tumor-selective adenovirus enadenotucirev with or without paclitaxel in platinum-resistant ovarian cancer: a phase 1 clinical trial.
Not available
S-EPMC8666888 | biostudies-literature
TranscriptomicsTCF4 and CDX2, major transcription factors for intestinal function, converge on the same cis-regulatory regions
Surprisingly few pathways signal between cells, raising questions about mechanisms for tissue-specific responses. In particular, Wnt ligands signal in many mammalian tissues, including the intestinal epithelium, where constitutive signaling causes cancer. Genome-wide analysis of DNA cis-regulatory r...
ORGANISM(S): Homo sapiens 
2010-08-11 | E-GEOD-22572 | biostudies-arrayexpress
TranscriptomicsHepatitis B virus-mediated alterations to the primary hepatocyte transcriptome [24 and 48 h]
Purpose: Chronic infection with hepatitis B virus is the leading global risk factor for the development of liver cancer. A large body of research has shown the many effects an HBV infection has on cellular physiology, particularly on pathways that may be involved in the development of HBV-associat...
ORGANISM(S): Rattus norvegicus 
2016-01-15 | E-GEOD-66566 | biostudies-arrayexpress
TranscriptomicsHepatitis B virus-mediated alterations to the primary hepatocyte transcriptome [Full Set]
Purpose: Chronic infection with hepatitis B virus is the leading global risk factor for the development of liver cancer. A large body of research has shown the many effects an HBV infection has on cellular physiology, particularly on pathways that may be involved in the development of HBV-associat...
ORGANISM(S): Rattus norvegicus 
2016-01-20 | E-GEOD-68112 | biostudies-arrayexpress
TranscriptomicsHigh-Resolution Profiling of Novel Transcribed Regions During Rat Spermatogenesis
Mammalian spermatogenesis is a complex and highly orchestrated combination of processes in which male germline proliferation and differentiation result in the production of mature spermatozoa. If recent genome-wide studies have contributed to the in-depth analysis of the male germline protein-coding...
ORGANISM(S): Rattus norvegicus 
2014-06-01 | E-GEOD-48321 | biostudies-arrayexpress
TranscriptomicsChronic exposure to ambient particulate matter alters cardiac gene expression patterns and markers of oxidative stress in rats
Exposure to ambient particulate matter (PM) significantly increases cardiovascular morbidity and mortality in the general population. We hypothesized that some components of PM can affect the gene expression patterns in the hearts of rats exposed for 3 months to filtered air (FA), coarse (CP; 2.5 < ...
ORGANISM(S): Rattus norvegicus 
2011-02-17 | E-GEOD-27179 | biostudies-arrayexpress
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