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TranscriptomicsBrucella melitensis global gene expression
In this study we report that B. melitensis at the late logarithmic phase of growth are more invasive for HeLa cells than at mid logarithmic or stationary growth phases. Microarray analysis of B. melitensis gene expression identified 414 up- and 40 down-regulated genes in late-log growth phase compar...
ORGANISM(S): Brucella melitensis 
2010-05-19 | E-GEOD-11192 | biostudies-arrayexpress
TranscriptomicsTranscripyome analysis of Brucella melitensis 16M and otpR mutant using Solexa/Illumina platform
We sequenced the mRNA of Brucella melitensis 16M and otpR mutant under acid stress to identify genes that were regulated by regulator OtpR. Examination of mRNA levels in individual sample under acid stress.
ORGANISM(S): Brucella melitensis 
2015-08-11 | E-GEOD-48165 | biostudies-arrayexpress
ProteomicsLabel-free quantitative proteomic analysis of Brucella abortus and Brucella melitensis
Brucella type strains (B. abortus 544 and B. melitensis 16 M), field-isolates (B. abortus T and B. melitensis C) were independently cultivated six times on Tryptic Soy Broth at 37 °C in the presence of 5% CO2 until mid-logarithmic phase. The cells were harvested by brief centrifugation and the bacte...
ORGANISM(S): Brucella abortus Brucella melitensis 
2020-06-11 | PXD006348 | Pride
Label free quantitative analysis Perseus software Brucella abortus Brucella melitensis Maxquant-andromeda Comparative proteomic analysis Ltq orbitrap velos mass spectrometer Maxquant software 
TranscriptomicsPrlR regulon in Brucella melitensis 16M
Investigation of whole genome gene expression level changes in a Brucella melitensis delta prlr mutant compared to the wild type strain. The mutants analyzed in this study are further described in A. Mirabella, R-M Yanez, R.M. Delrue, S. Uzureau, M.S. Zygmunt, A. Cloeckaert, X. De Bolle, J.J. Letess...
ORGANISM(S): Brucella melitensis bv. 1 str. 16M 
2012-12-31 | E-GEOD-34633 | biostudies-arrayexpress
ProteomicsComparative proteomics of Brucella melitensis 16M and REV1
Brucellosis is a zoonosis of the Mediterranean and Middle-East regions linked to important economic losses and reduced animal welfare. To date, no effective diagnostic and/or prophylactic measures are available for the control of brucellosis, due to the residual virulence of the bacterial strain adm...
ORGANISM(S): Brucella melitensis bv. 1 str. 16M 
2021-05-20 | PXD022472 | Pride
Hdmse 16m Rev1 Label-free Brucella melitensis 
TranscriptomicsIntracellular Brucella melitensis gene expression
Brucella spp. is an intracellular pathogen in vivo. The intracellular B. melitensis transcriptome was determined by initially enriched and then amplified B. melitensis RNA from total RNA of B. melitensis-infected HeLa cells. Analysis of microarray results identified 161 and 115 genes differentially ...
ORGANISM(S): Brucella melitensis 
2012-12-27 | E-GEOD-14704 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 2)
Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteri...
ORGANISM(S): Brucella canis 
2012-12-01 | E-GEOD-34498 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse macrophages infected with B. melitensis
Facultative intracellular Brucella infect and survive inside macrophages, and the outcome of macrophage-Brucella interaction is a basis for establishment of a chronic Brucella infection. The majority of Brucella are killed at the early infection stage. A subpopulation of virulent Brucella strains is...
ORGANISM(S): Mus musculus 
2008-06-13 | E-GEOD-5202 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 4)
Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteri...
ORGANISM(S): Brucella canis 
2012-12-01 | E-GEOD-34503 | biostudies-arrayexpress
TranscriptomicsDifferential Expression of Iron Acquisition Genes by Brucella melitensis and Brucella canis During Macrophage Infection (part 1)
Brucella melitensis and Brucella canis differ by ~75 genes yet B. melitensis is highly virulent for humans while B. canis is considered rarely pathogenic. No identified bacterial factors or mechanisms account for this difference in virulence. To identify functional differences of these two bacteri...
ORGANISM(S): Brucella melitensis bv. 1 str. 16M 
2012-12-01 | E-GEOD-34495 | biostudies-arrayexpress
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