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At presynaptic active zones (AZs), scaffold proteins are critical for coordinating synaptic vesicle (SV) release and forming essential nanoarchitectures. However, regulatory principles steering AZ scaffold assembly, function, and plasticity remain insufficiently understood. We here identify a novel ...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2025-03-17 | PXD058345 | Pride
Transcriptome analysis of Drosophila melanogaster intestines upon knockdown of Tachykinin (Tk), the GPCR GulpR (CG32547), and bruchpilot (brp)
The function of the nervous system relies on tightly regulated, yet plastic synaptic vesicle release machinery at the presynaptic active zone. In Drosophila, a form of presynaptic active zone plasticity, Presynaptic Scaling, or PreScale, is executed by the ELKS-family scaffold protein Bruchpilot (BR...
ORGANISM(S): Drosophila melanogaster (Fruit fly) 
2026-06-09 | PXD067034 | Pride
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