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TranscriptomicsTranscription profiling by array of human breast cancer cell line BT-474 with annexin A1 over-expression or silenced with siRNA to demonstrate design of multi-condition experiments
Multiple-condition experiment was desinged to be any number of conditions in an experiment without replicate observations for microarray and used to identify genes differentially expressed between different pairs of conditions (treatments).
In this study we used breast cancer stable cell lines f...
ORGANISM(S): Homo sapiens 
2010-06-26 | E-MEXP-2775 | biostudies-arrayexpress
ProteomicsMass spectroscopy-based proteomics and metabolomics analysis of BT- 474 breast cancer cells treated with Tamoxifen and/or Trastuzumab
`Triple positive` BT-474 breast cancer cells were treated with anti-cancer compounds, Tamoxifen and Trastuzumab, and the metabolome and proteome analysed by LC-MS/MS using a timsTOF.
ORGANISM(S): Homo sapiens (Human) 
2023-01-17 | PXD033145 | Pride
Anti-cancer Lc-msms Timstof Human Cells 
GenomicsWhole genome sequence analysis of BT-474 using Complete Genomics’ standard and Long Read Fragment technologies
Whole genome sequence analysis of BT-474 using Complete Genomics’ standard and Long Read Fragment technologies
PRJEB10587 | ENA
GenomicsIdentification of several potential chromatin binding sites of HOXB7 and its downstream target genes in breast cancer
We report the chromatin binding sites of HOXB7 transcription factor in BT-474 breast cancer cell line using ChIP-sequencing. We validated the chromatin binding sites in BT-474, MDA-MB-361, MCF7 and T-47D breast cancer cell lines using ChIP-qPCR. The ChIP experiments have been performed using HOXB7 a...
ORGANISM(S): Homo sapiens 
2015-06-08 | E-GEOD-47164 | biostudies-arrayexpress
GenomicsSingle-cell full-length RNA-sequencing of MCF7 and BT-474 cells using down-scaled Smart-seq2
Single-cell full-length RNA-sequencing of MCF7 and BT-474 cells using down-scaled Smart-seq2
PRJNA831806 | ENA
GenomicsEffect of MetAP2 the inhibitor SDX-7320 on gene expression in BT-474 xenografts
Effect of MetAP2 the inhibitor SDX-7320 on gene expression in BT-474 xenografts
PRJNA962135 | ENA
TranscriptomicsSingle-cell full-length RNA-sequencing of MCF7 and BT-474 cells using down-scaled Smart-seq2
We report single-cell RNA-sequencing data of wild type, breast cancer cells MCF7 and BT-474. Single cells were isolated using the F.SIGHT single cell dispenser. cNDA synthesis and library preparation were down-scaled to 1/10 of original reaction volumes. By comparative UMAP clustering we could show ...
ORGANISM(S): Homo sapiens 
2023-12-31 | GSE201443 | GEO
GenomicsERRalpha mediates metabolic adaptations that drive lapatinib resistance in breast cancer (ERRalpha binding profiles in breast cancer cells by ChIP-seq)
Ablation of ERRalpha significantly delays ERBB2-induced mammary tumorigenesis and ERRalpha regulates genes of the ERBB2 amplicon. To further investigate the relationship between ERRalpha activity and RTK signaling, we mapped ERRalpha binding sites in SKBr3 cells upon EGF treatment or heregulin treat...
ORGANISM(S): Homo sapiens 
2016-06-15 | E-GEOD-81651 | biostudies-arrayexpress
TranscriptomicsProfiling of p53-responsive genes in human breast cancer cells harboring endogenous ts-p53 E285K
The ts-p53 E285K protein is a rare p53 mutant with temperature-sensitive (ts) loss of function characteristics. In cancer cells, which express ts-p53 E285K intrinsically, endogenous wild type p53 activity is reconstituted by appropriate cultivation temperature (permissive condition). At non-appropri...
ORGANISM(S): Homo sapiens 
2012-12-31 | E-GEOD-35006 | biostudies-arrayexpress
ProteomicsLarge-Scale Analysis of Breast Cancer-Related Conformational Changes in Proteins using SILAC-SPROX
Proteomic methods for disease state characterization and biomarker discovery have traditionally utilized quantitative mass spectrometry methods to identify proteins with altered expression levels in disease states. Here we report on the large-scale use of protein folding stability measurements to ch...
ORGANISM(S): Homo sapiens (Human) 
2017-07-10 | PXD006703 | Pride
Mcf-7 Chemical denaturation Bt-474 Mda-mb-468 Protein folding 
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