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ProteomicsC-terminal Domain Small Phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
The RE1 Silencing Transcription Factor (REST) in stem cells represses hundreds of genes essential to neuronal function. During neurogenesis, REST is degraded in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype. Prior studies indicate that part of the degradation ...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-09-15 | PXD001127 | Pride
Erk Pin1 Neuronal differentiation. Re1 silencing transcription factor Btrcp Ctdsp1 Rest 
UnknownEpigenetic modulator inhibition overcomes temozolomide chemoresistance and antagonizes tumor recurrence of glioblastoma.
Not available
S-EPMC7598052 | biostudies-literature
GenomicsSUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness
Alteration of the size and stiffness of the nucleus triggered by environmental cues are thought to be important for eukaryotic cell fate and function. Here we identify the nuclear envelope proteins SUN1/2 as mechano-regulators of the nucleus during M1 polarization of the macrophage. Specifically, we...
ORGANISM(S): Mus musculus 
2023-09-28 | GSE243684 | GEO
GenomicsSUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness
SUN1/2 Controls Macrophage Polarization via Modulating Nuclear Size and Stiffness
PRJNA1019379 | ENA
TranscriptomicsIdentification of differentially expressed miRNAs in HCC cell lines compared with normal livers
To explore functionally crucial tumor-suppressive (TS)-miRNAs in hepatocellular carcinoma (HCC), we performed integrative function- and expression-based screenings of TS-miRNAs in six HCC cell lines. The screenings identified seven miRNAs, which showed growth-suppressive activities through the over...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-41077 | biostudies-arrayexpress
TranscriptomicsAnalysis of miRNA profile in Ago2-IP fraction after miR-195 or miR-497 overexpression
To explore functionally crucial tumor-suppressive (TS)-miRNAs in hepatocellular carcinoma (HCC), we performed integrative function- and expression-based screenings of TS-miRNAs in six HCC cell lines. The screenings identified seven miRNAs, which showed growth-suppressive activities through the over...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-41079 | biostudies-arrayexpress
TranscriptomicsNext Generation Sequencing Facilitates Quantitative Analysis of Argonaute 2 (Ago2)-immunoprecipitation (IP) after miR-195 or miR-497 overexpression in HepG2
To explore functionally crucial tumor-suppressive (TS)-miRNAs in hepatocellular carcinoma (HCC), we performed integrative function- and expression-based screenings of TS-miRNAs in six HCC cell lines. The screenings identified seven miRNAs, which showed growth-suppressive activities through the over...
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-41074 | biostudies-arrayexpress
ProteomicsBioID-based identification of SCF-BTrCP1/2 E3 ligase substrates
RAW files, mzML files, search results (gpm.xml), TPP analysis files (pep.XML and prot.XML, as well as tab delimited output of pep.XML as .xls) and analyzed results Table 1 for the identification of BTRCP1/2 substrates using BioID. The identification of ubiquitin E3 ligase substrates has been extreme...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-02-04 | MSV000079032 | MassIVE
ProteomicsBioID-based identification of SCF-BTrCP1/2 E3 ligase substrates
RAW files, mzML files, search results (gpm.xml), TPP analysis files (pep.XML and prot.XML, as well as tab delimited output of pep.XML as .xls) and analyzed results Table 1 for the identification of BTRCP1/2 substrates using BioID. The identification of ubiquitin E3 ligase substrates has been extrem...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2015-01-12 | MSV000078991 | MassIVE
TranscriptomicsArgonaute 2
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-05-31 | E-GEOD-41081 | biostudies-arrayexpress
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