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GenomicsPolycomb Repressor Complex 2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype.
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results showed that a majority of REST-bound genomic regions were not associated with H3K27me3 enrichment and loss of H3K27me3 enrichment was not a g...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-48320 | biostudies-arrayexpress
TranscriptomicsPolycomb Repressor Complex2 and REST-associated histone deacetylases are independent pathways toward a mature neuronal phenotype
These experiments were designed to test the hypothesis that REST and Polycomb Repressor Complex 2 function cooperatively in undifferentiated ESCs. Our results show that H3K27me3-enriched genes show no de-repression in REST-/- ESCs, while REST target genes show significant de-repression. RNA-seq was ...
ORGANISM(S): Mus musculus 
2014-09-30 | E-GEOD-59442 | biostudies-arrayexpress
GenomicsGenome-wide mapping of REST-bound sites in human CD4+ T cells
We performed ChIP-seq to identify genome-wide REST (NRSF) binding in the human CD4+ T cells. The data were compared to REST occupancy in additional 15 human cell types analyzed by the ENCODE project (GSE32465) in order to study the dynamics and context-dependent functions of REST-chromatin interacti...
ORGANISM(S): Homo sapiens 
2014-08-06 | E-GEOD-49570 | biostudies-arrayexpress
TranscriptomicsGenome-wide analysis of REST knockdown responsive gene expression in mouse ES cells
Analysis of gene expression profiling upon REST shRNA knockdown in mouse ES cells for 72 hours, Total RNA obtained from pSuper vector control and REST shRNA treatment for 72 hours using Invitrogen RNA extraction kit.
ORGANISM(S): Mus musculus 
2011-04-01 | E-GEOD-28141 | biostudies-arrayexpress
GenomicsREST–Mediated Recruitment of Polycomb Repressor Complexes in Mammalian Cells
Genome-wide analysis of REST and Polycomb binding in Rest-/- and Eed-/- mouse embryonic stem (mES) cells showed that Rest was required for PRC1 recruitment to a subset of Polycomb regulated neuronal genes. Furthermore, we found that PRC1 can be recruited to Rest binding sites independently of CpG is...
ORGANISM(S): Mus musculus 
2013-06-20 | E-GEOD-48122 | biostudies-arrayexpress
ProteomicsC-terminal Domain Small Phosphatase 1 and MAP kinase reciprocally control REST stability and neuronal differentiation.
The RE1 Silencing Transcription Factor (REST) in stem cells represses hundreds of genes essential to neuronal function. During neurogenesis, REST is degraded in neural progenitors to promote subsequent elaboration of a mature neuronal phenotype. Prior studies indicate that part of the degradation ...
ORGANISM(S): Rattus norvegicus (Rat) 
2014-09-15 | PXD001127 | Pride
Erk Pin1 Neuronal differentiation. Re1 silencing transcription factor Btrcp Ctdsp1 Rest 
TranscriptomicsChromatin immunoprecipitation of REST/NRSF
ENCODE ChIP-chip study using 8 diverse human cell lines; 4 of neural origin (NB69, KELLY, SHSY-5Y, U373) and 4 of non-neural origin (HeLa, HepG2, HEK293 and K562) and anti-REST/NRSF antibody (Santa Cruz Biotech; sc-25398 aka H290) to asses REST-genome interactions across 1% of the human genome used...
ORGANISM(S): Homo sapiens 
2009-03-31 | E-TABM-660 | biostudies-arrayexpress
TranscriptomicsSRRM4 Expression and the Loss of REST Activity May Promote the Emergence of the Neuroendocrine Phenotype in Castration-Resistant Prostate Cancer
The neuroendocrine (NE) phenotype is associated with the development of metastatic castration-resistant prostate cancer (CRPC). Our objective was to characterize the molecular features of the NE phenotype in CRPC. Expression of chromogranin A (CHGA), synaptophysin (SYP), androgen receptor (AR), and ...
ORGANISM(S): Homo sapiens 
2015-06-24 | E-GEOD-66187 | biostudies-arrayexpress
GenomicsRole of REST during neuronal differentiation
This SuperSeries is composed of the following subset Series: GSE27114: Expression data from REST knock-out versus REST wild type cells during in vitro neurogenesis GSE27148: A comparative epigenomics approach reveals REST as a mediator of Polycomb reprogramming during neuronal differentiation Refer ...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-27341 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of mouse E10.5 limb bud ZPA and the rest of the E10.5 limb bud from Shhgfpcre heterozygotes separated by FACS
Comparing gene expression of cells from the E10.5 limb bud ZPA and the rest of the E10.5 limb bud from Shhgfpcre heterozygotes separated by FACS. Experiment Overall Design: 8 samples, 4 ZPA and 4 rest of the limb
ORGANISM(S): Mus musculus 
2008-06-15 | E-GEOD-7598 | biostudies-arrayexpress
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